Results 1 to 10 of about 9,894 (179)

Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis [PDF]

BMC Plant Biology, 2022
Background Taxol from Taxus species is a precious drug used for the treatment of cancer and can effectively inhibit the proliferation of cancer cells. However, the growth of Taxus plants is very slow and the content of taxol is quite low.
Xiaoying Cao, Lingxia Xu, Jingyi Wang, Mengmeng Dong, Chunyan Xu, Guoyin Kai, Wen Wan, Jihong Jiang   +7 more
doaj   +5 more sources

TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis [PDF]

Frontiers in Plant Science, 2022
Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Xiaoying Cao, Lingxia Xu, Ludan Li, Wen Wan, Jihong Jiang   +4 more
doaj   +5 more sources

Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways [PDF]

Frontiers in Plant Science, 2021
Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Ying Chen, Ying Chen, Ying Chen, Hua Zhang, Hua Zhang, Hua Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Wenli Zhang, Wenli Zhang, Wenli Zhang, Ziqi Ou, Ziqi Ou, Ziqi Ou, Zehang Peng, Zehang Peng, Zehang Peng, Chunhua Fu, Chunhua Fu, Chunhua Fu, Chunfang Zhao, Chunfang Zhao, Chunfang Zhao, Longjiang Yu, Longjiang Yu, Longjiang Yu   +26 more
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Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees [PDF]

BMC Plant Biology, 2021
Background Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. Results High accumulation of 10-DAB, taxol, and 7-E-
Chunna Yu, Chengchao Zhang, Xinyun Xu, Jiefang Huang, Yueyue Chen, Xiujun Luo, Huizhong Wang, Chenjia Shen   +7 more
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Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis [PDF]

BMC Plant Biology, 2019
Background Taxus cuspidata is well known worldwide for its ability to produce Taxol, one of the top-selling natural anticancer drugs. However, current Taxol production cannot match the increasing needs of the market, and novel strategies should be ...
Xuejun Kuang, Sijie Sun, Jianhe Wei, Ying Li, Chao Sun   +4 more
doaj   +2 more sources

Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species [PDF]

BMC Plant Biology, 2019
Background Taxol is an efficient anticancer drug; however, the accumulation of taxoids can vary hugely among Taxus species. The mechanism underlying differential accumulation of taxoids is largely unknown. Thus, comparative analysis of the transcriptomes
Ting Zhou, Xiujun Luo, Chunna Yu, Chengchao Zhang, Lei Zhang, Yao-bin Song, Ming Dong, Chenjia Shen   +7 more
doaj   +2 more sources

TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis [PDF]

Frontiers in Plant Science, 2018
The multitherapeutic taxol, which can be obtained from Taxus spp., is the most widely used anticancer drug. Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants.
Meng Zhang, Meng Zhang, Xiaofei Jin, Xiaofei Jin, Ying Chen, Ying Chen, Mi Wei, Mi Wei, Weifang Liao, Weifang Liao, Shengying Zhao, Shengying Zhao, Chunhua Fu, Chunhua Fu, Longjiang Yu, Longjiang Yu   +15 more
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Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
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Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis [PDF]

BMC Microbiology
Background Taxol, derived from Taxus trees, is a valuable natural resource for the development of anticancer drugs. Endophytic fungi from Taxus trees are a promising alternative source of Taxol.
Hongshan Zhang, Wanting Lin, Ruoyun Ma, Yue Zang, Kailin Hou, Zhen Xu, Xiaoyun Xi, Weiting Zhang, Shini Tang, Xueshuang Liang, Yiming Sun, Chenjia Shen   +11 more
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Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis [PDF]

Nature Communications
As a sister genus to Taxus, Pseudotaxus holds significant importance for studying the origin and evolution of the taxane biosynthesis pathway. However, the reference genome of Pseudotaxus chienii is yet unavailable.
Mingshuang Wang, Ruoyun Ma, Zijin Fang, Lingxiao Zhang, Yibo Zhang, Mengyin Zheng, Enhui Bai, Wanting Lin, Yanyan Pei, Yue Zang, Huijie Ma, Shangguo Feng, Xiaori Zhan, Chunna Yu, Shuling Wang, Huizhong Wang, Chenliang Yu, Chenjia Shen   +17 more
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