Results 91 to 100 of about 10,148 (237)

Gram‐Scale Access to (3,11)‐Cyclotaxanes—Synthesis of 1‐Hydroxytaxuspine C

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Belonging to the family of complex taxanes, 1‐hydroxytaxuspine C is a densely functionalized natural product. The synthesis was realized via a semisynthetic approach, starting from commercially available 10‐deacetylbaccatin III. A late‐stage photocyclization was utilized to install the characteristic transannular bond of complex taxanes, transforming ...
Philipp Schoch, Yulia Krivolapova, Fabian Schneider, Lu Pan, Tanja Gaich   +4 more
wiley   +1 more source

Engineering Isoprenoid Biosynthesis inArtemisia annuaL. for the Production of Taxadiene: A Key Intermediate of Taxol [PDF]

BioMed Research International, 2015
Taxadiene is the first committed precursor to paclitaxel, marketed as Taxol, arguably the most important anticancer agent against ovarian and breast cancer. InTaxus, taxadiene is directly synthesized from geranylgeranyl diphosphate (GGPP) that is the common precursor for diterpenoids and is found in most plants and microbes.
Fusheng Jiang, Zhiqi Miao, Meiya Li, Xiangli Yu   +3 more
openaire   +2 more sources

High efficiency protoplast isolation from in vitro cultures and hairy roots of Maesa lanceolata [PDF]

, 2010
In vitro cultures of the medicinal plant Maesa lanceolata were established to enable the cultivation of plant material for the production of protoplasts.
Geelen, Danny, Lambert, Ellen
core   +1 more source

Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production

Frontiers in Microbiology, 2019
Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The
Ingy I. Abdallah, Hegar Pramastya, Hegar Pramastya, Ronald van Merkerk, Sukrasno, Wim J. Quax   +5 more
doaj   +1 more source

Diterpene Synthases and Their Responsible Cyclic Natural Products [PDF]

, 2014
This review provides an overview of diterpene synthases which were initially identified via genetic and/or biochemical means, traversing all organisms researched to ...
Hai-Yan Gong, Xiao-Ya Chen, Ying Zeng
core   +1 more source

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla, Rabin Neupane, Saloni Sood, Noor Hussein, Mariam Abou‐Dahech, David Terrero, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +8 more
wiley   +1 more source

A cDNA Clone for Taxadiene Synthase, the Diterpene Cyclase That Catalyzes the Committed Step of Taxol Biosynthesis [PDF]

Journal of Biological Chemistry, 1996
The committed step of taxol (paclitaxel) biosynthesis is catalyzed by taxa-4(5),11(12)-diene synthase, a diterpene cyclase responsible for transforming the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to the parent olefin with a taxane skeleton.
Mark R. Wildung, Rodney Croteau
openaire   +3 more sources

Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway? [PDF]

, 2016
We have shown for the first time that taxadiene (3) can be epoxidised in a regio- and diastereoselective manner to provide taxadiene-4(5)-epoxide (12) as a single diastereoisomer, and that this epoxide can be rearranged to give taxa-4(20),11(12)-dien-5α ...
Adam, Ajikumar, Angelis, Barbosa Sousa, Braude, Cragg, Danishefsky, DeJong, Doi, Edgar, Engels, Groves, Hanzlik, Hefner, Holton, Holton, Holton, Huang, Huang, Huang, Ishihara, Jennewein, Kingston, Koepp, Kovacs, Köksal, Liebler, Maruoka, Mendoza, Morihira, Mukaiyama, Murakami, Nicolaou, Parker, Rontein, Rubenstein, Traylor, Uroos, Wang, Wani, Wender, Wilde, Yadav, Yasuda   +43 more
core   +1 more source

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review

Phytotherapy Research, Volume 39, Issue 8, Page 3601-3612, August 2025.
Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley   +1 more source

Advances in Pathway Engineering for Natural Product Biosynthesis [PDF]

, 2015
Biocatalysts provide an efficient, inexpensive and environmentally friendly alternative to traditional organic synthesis, especially for compounds with complex stereochemistries.
Aharoni, Ajikumar, Ajikumar, Albertsen, Andrianantoandro, Anthony, Asadollahi, Atsumi, Bailey, Biggs, Boucher, Butler, Báez-Viveros, Cane, Chang, Chemler, Chemler, Chemler, Chen, Chin, Connor, Croteau, Das, David, Dueber, Ehsani, Engels, Fang, Farmer, Farré, Fischbach, Fischbach, Forkmann, Giessen, Gillam, Gosset, Greenhagen, Gruchattka, Hawkins, Hodgman, Huang, Hughes, Hwang, Ikeda, Jang, Jiang, Jiang, Johannes, Jordan, Julsing, Juminaga, Jung, Katsuyama, Khalil, Khersonsky, Khersonsky, Khersonsky, Khosla, Kim, Kirby, Kizer, Klayman, Knaggs, Lee, Lee, Leonard, Leonard, Leonard, Leonard, Li, Lindahl, Lütke-Eversloh, Ma, Malla, Marienhagen, Martin, Martínez, Menzella, Miles, Minami, Miyahisa, Ohto, Paddon, Paradise, Pfeifer, Pickens, Pulido, Reiling, Ro, Ro, Rodríguez-Concepción, Rokem, Ryan, Röthlisberger, Santos, Scalcinati, Scalcinati, Schmidt-Dannert, Shen, Shiba, Siddiqui, Siegel, Siegel, Strohl, Sung, Thirlway, Umeno, Umeno, Vannelli, Vedula, Wang, Wang, Wang, Wang, Wilkinson, Wu, Yadav, Yan, Yang, Yoshikuni, Yoshikuni, Zerbe, Zha, Zhang, Zhang, Zhou, Zhou, Zhu   +127 more
core   +1 more source