Association of endometrioid ovarian carcinoma arising from endometriosis, endometrioid endometrial carcinoma, and high-grade undifferentiated endometrial sarcoma. a case report [PDF]
, 2017 Endometriosis is a chronic disease that affects women of reproductive age. Malignant transformation in endometriosis is considered to be an unusual event, only occurring in 0.7-0.1% of cases.
Caserta, D. +3 more
core +1 more source
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications
Cell Proliferation, Volume 58, Issue 10, October 2025.Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su +5 more
wiley +1 more source
Advances in Pathway Engineering for Natural Product Biosynthesis [PDF]
, 2015 Biocatalysts provide an efficient, inexpensive and environmentally friendly alternative to traditional organic synthesis, especially for compounds with complex stereochemistries.
Aharoni +127 more
core +1 more source
Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis. [PDF]
Arch Biochem Biophys, 2008 The last few steps in the biosynthesis of the anticancer drug Taxol in yew (Taxus) species are thought to involve the attachment of beta-phenylalanine to the C13-O-position of the advanced taxane diterpenoid intermediate baccatin III to yield N-debenzoyl-2'-deoxytaxol, followed by hydroxylation on the side chain at the C2'-position to afford N ...
Long RM +3 more
europepmc +4 more sources
Plant Biotechnology Journal, Volume 23, Issue 10, Page 4461-4476, October 2025.Summary Revealing the multicellular compartmentalization map is crucial for plant breeding and metabolism regulation. Despite the importance of triterpenes as active compounds, there has been no report on their biosynthetic multicellular mapping. In this study, ginsenosides are used as an example to reveal the multicellular compartmentalization map of ...
Rubing Wang +8 more
wiley +1 more source
Hazel (Corylus avellana L.) as a New Source of Taxol and Taxanes
Journal of Medicinal Plants, 2012 Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi’s carcinoma, and was originally obtained from bark of taxus brevifolia.
A Qaderi +6 more
doaj
Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation [PDF]
, 2017 We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre.
Ebel, Rainer +4 more
core +2 more sources
Use of endophytic fungi in the Taxol anticancer drug production
Biotecnología Vegetal, 2014 Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. Taxol is obtained from Taxus spp. trees. It is found in low concentrations in the bark, needles and roots.
Hebert Jair Barrales-Cureño +1 more
doaj
Methyl Jasmonate Regulates Podophyllotoxin Accumulation in Podophyllum hexandrum by Altering the ROS-Responsive Podophyllotoxin Pathway Gene Expression Additionally through the Down Regulation of Few Interfering miRNAs [PDF]
, 2017 Podophylloxin (ptox), primarily obtained from Podophyllum hexandrum, is the precursor for semi-synthetic anticancer drugs viz. etoposide, etopophos, and teniposide.
Apel +46 more
core +1 more source
Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids [PDF]
, 2016 Background De novo production of multi-hydroxylated diterpenoids is challenging due to the lack of efficient redox systems. Results In this study a new reductase/ferredoxin system from Streptomyces afghaniensis (AfR·Afx) was identified, which allowed ...
Bernhard Loll +7 more
core +3 more sources