Results 11 to 20 of about 342,717 (183)

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III. [PDF]

Nature
Plants make complex and potent therapeutic molecules1,2, but sourcing these molecules from natural producers or through chemical synthesis is difficult, which limits their use in the clinic.
McClune CJ, Liu JC, Wick C, De La Peña R, Lange BM, Fordyce PM, Sattely ES.   +6 more
europepmc   +2 more sources

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol

Nature Communications
Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have been characterized, stepwise biosynthetic ...
Chengshuai Yang, Yan Wang, Zhen Su, Lunyi Xiong, Pingping Wang, Wen Lei, Xing Yan, Dawei Ma, Guoping Zhao, Zhihua Zhou   +9 more
doaj   +2 more sources

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +2 more sources

Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis [PDF]

BMC Microbiology
Background Taxol, derived from Taxus trees, is a valuable natural resource for the development of anticancer drugs. Endophytic fungi from Taxus trees are a promising alternative source of Taxol.
Hongshan Zhang, Wanting Lin, Ruoyun Ma, Yue Zang, Kailin Hou, Zhen Xu, Xiaoyun Xi, Weiting Zhang, Shini Tang, Xueshuang Liang, Yiming Sun, Chenjia Shen   +11 more
doaj   +2 more sources

Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis [PDF]

Nature Communications
As a sister genus to Taxus, Pseudotaxus holds significant importance for studying the origin and evolution of the taxane biosynthesis pathway. However, the reference genome of Pseudotaxus chienii is yet unavailable.
Mingshuang Wang, Ruoyun Ma, Zijin Fang, Lingxiao Zhang, Yibo Zhang, Mengyin Zheng, Enhui Bai, Wanting Lin, Yanyan Pei, Yue Zang, Huijie Ma, Shangguo Feng, Xiaori Zhan, Chunna Yu, Shuling Wang, Huizhong Wang, Chenliang Yu, Chenjia Shen   +17 more
doaj   +2 more sources

Getting to the bottom of Taxol biosynthesis by fungi

Fungal Diversity, 2013
Taxol (paclitaxel) is a highly-oxygenated diterpenoid natural product first isolated from the pacific yew tree (Taxus brevifolia). It is one of the most widely used anticancer drugs. Soon after the discovery of its unique mode of action and the resulting
Stefan Jennewein
exaly   +2 more sources

Transcriptome and Metabolome Analyses of Taxus chinensis var. mairei Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis [PDF]

Plants
Taxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear.
Luyuan Jiang, Yanyan Li, Xiaoyang Jiang, Fenjuan Shao, Wenli Wu, Fan Xu, Iain Wilson, Angela Hoffman, Yanfang Yang, Deyou Qiu   +9 more
doaj   +2 more sources

Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production

Frontiers in Microbiology, 2019
Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The
Ingy I. Abdallah, Hegar Pramastya, Hegar Pramastya, Ronald van Merkerk, Sukrasno, Wim J. Quax   +5 more
doaj   +2 more sources

Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide [PDF]

Biotechnology for Biofuels and Bioproducts
Taxol serves as an efficient natural anticancer agent with extensive applications in the treatment of diverse malignancies. Although advances in synthetic biology have enabled the de novo synthesis of taxol precursors in various microbial chassis, the ...
Jialing Zhong, Yushu Wang, Zhuoyang Chen, Yaliqin Yalikun, Lin He, Tiangang Liu, Gang Ma   +6 more
doaj   +2 more sources

Transcription level differences in Taxus wallichiana var. mairei elicited by Ce3+, Ce4+ and methyl jasmonate

Frontiers in Plant Science, 2022
Taxol is a precious and effective anticancer drug. Cerium and methyl jasmonate (MJ) have been shown to increase the yield of taxol in taxus cells. However, the mechanisms of cerium-mediated and MJ-mediated taxol biosynthesis remain unknown.
Na Han, Wen-ji Geng, Jian Li, Shu-ting Liu, Jie Zhang, Yi-jie Wen, Huai-hua Xu, Meng-yuan Li, Yan-ru Li, Pei-pei Han   +9 more
doaj   +1 more source