Results 11 to 20 of about 327,793 (259)

Insights into Taxol® biosynthesis by endophytic fungi [PDF]

Applied Microbiology and Biotechnology, 2023
There have been two hundred reports that endophytic fungi produce Taxol®, but its production yield is often rather low. Although considerable efforts have been made to increase Taxol/taxanes production in fungi by manipulating cocultures, mutagenesis ...
Subban Kamalraj, Frank Kempken
semanticscholar   +4 more sources

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III. [PDF]

Nature
Plants make complex and potent therapeutic molecules1,2, but sourcing these molecules from natural producers or through chemical synthesis is difficult, which limits their use in the clinic.
McClune CJ, Liu JC, Wick C, De La Peña R, Lange BM, Fordyce PM, Sattely ES.   +6 more
europepmc   +3 more sources

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol

Nature Communications
Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have been characterized, stepwise biosynthetic ...
Chengshuai Yang, Yan Wang, Zhen Su, Lunyi Xiong, Pingping Wang, Wen Lei, Xing Yan, Dawei Ma, Guoping Zhao, Zhihua Zhou   +9 more
doaj   +4 more sources

TcJAV3-TcWRKY26 Cascade Is a Missing Link in the Jasmonate-Activated Expression of Taxol Biosynthesis Gene DBAT in Taxus chinensis. [PDF]

Int J Mol Sci, 2022
Jasmonates (JAs) are the most effective inducers for the biosynthesis of various secondary metabolites. Currently, jasmonate ZIM domain (JAZ) and its interactors, such as MYC2, constitute the main JA signal transduction cascade, and such a cascade fails ...
Chen L, Wu L, Yang L, Yu H, Huang P, Wang Y, Yao R, Zhang M.   +7 more
europepmc   +2 more sources

ComputationalInvestigation of Cytochrome P450-CatalyzedOxetane Formation in Taxol Biosynthesis

Biochemistry
Paclitaxel (Taxol) is widely recognized as one of the most effective natural anticancer drugs, yet its production is limited by its scarce natural supply and the low yields obtained from its chemical synthesis.
Surajit Nandi (3368402), Rohan Sharma (15926083), Subhajit Mandal (1542127), Pankaz K. Sharma (2506255), Parayil Kumaran Ajikumar (2488570), Anakuthil Anoop (1433272)   +5 more
semanticscholar   +3 more sources

Taxol Biosynthesis and Molecular Genetics [PDF]

Phytochemistry Reviews, 2006
Biosynthesis of the anticancer drug Taxol in Taxus (yew) species involves 19 steps from the universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial methyl erythritol phosphate pathway for isoprenoid precursor supply. Following the committed cyclization to the taxane skeleton, eight cytochrome P450-mediated oxygenations ...
Croteau R, Ketchum RE, Long RM, Kaspera R, Wildung MR.   +4 more
exaly   +5 more sources

Screening of taxol biosynthesis-related genes in taxol produced from Nodulisporium sylviforme HDF-68 by mRNA differential display [PDF]

Annals of Microbiology, 2014
Differential expressed genes in taxol producing Nodulisporium sylviforme HDF-68 at different periods of fermentation were analyzed by mRNA differential display. A total of 38 fragments were found expressed differentially during taxol synthesis phase. Using reverse Northern blot analysis, the hybridization signals of 16 fragments were consistent with ...
Kai Zhao, Ye Xiao, Chao Wang, Dan Liu, Yue Zhang, Xin Wang, Xiuliang Li, Tao Jin   +7 more
semanticscholar   +4 more sources

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors [PDF]

bioRxiv
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-cancer therapeutic paclitaxel (Taxol®).
Conor J. McClune, Chun‐Ting Liu, Chloe Wick, Ricardo De La Peña, B. Markus Lange, Polly M. Fordyce, Elizabeth S. Sattely   +6 more
openalex   +2 more sources

Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis [PDF]

BMC Microbiology
Background Taxol, derived from Taxus trees, is a valuable natural resource for the development of anticancer drugs. Endophytic fungi from Taxus trees are a promising alternative source of Taxol.
Hongshan Zhang, Wanting Lin, Ruoyun Ma, Yue Zang, Kailin Hou, Zhen Xu, Xiaoyun Xi, Weiting Zhang, Shini Tang, Xueshuang Liang, Yiming Sun, Chenjia Shen   +11 more
doaj   +2 more sources

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +2 more sources