Results 21 to 30 of about 342,786 (231)
Insights into Taxol® biosynthesis by endophytic fungi
Applied Microbiology and Biotechnology, 2023 There have been two hundred reports that endophytic fungi produce Taxol®, but its production yield is often rather low. Although considerable efforts have been made to increase Taxol/taxanes production in fungi by manipulating cocultures, mutagenesis ...
Kamalraj Subban, F. Kempken
semanticscholar +3 more sources
Chemistry & Biology, 2004 Cytochrome P450 monooxygenases play a prominent role in the biosynthesis of the diterpenoid anticancer drug Taxol, as they appear to constitute about half of the 19 enzymatic steps of the pathway in yew (Taxus) species. A combination of classical biochemical and molecular methods, including cell-free enzyme studies and differential-display of mRNA ...
Chau, MyDoanh +3 more
+10 more sources
Enhancement of Paclitaxel's Anticancer Efficacy in Thyroid Cancer by Isodeoxyelephantopin Through Modulation of Oxidative Stress. [PDF]
Food Sci NutrIsodeoxyelephantopin (IDET) enhances paclitaxel sensitivity in thyroid cancer by promoting ROS‐mediated apoptosis through inhibition of the p62‐Keap1‐Nrf2 antioxidant pathway. The combination treatment suppresses tumor growth and metastasis with minimal toxicity, suggesting IDET as a safe and effective chemosensitizer to improve Taxol‐based therapy ...
Cong W, Sun J, Hao Z, Gong M.
europepmc +2 more sources
Baseline survey of root-associated microbes of Taxus chinensis (Pilger) Rehd. [PDF]
PLoS ONE, 2015 Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al.
Qian Zhang +7 more
doaj +1 more source
Taxol Biosynthesis: An Update [PDF]
Planta Medica, 1997 The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production.
M, Hezari, R, Croteau
openaire +2 more sources
Microbiology Research, 2023 Attenuating the Taxol productivity of fungi with the subculturing and storage under axenic conditions is the challenge that halts the feasibility of fungi to be an industrial platform for Taxol production.
Nabil Z. Mohamed +3 more
semanticscholar +1 more source
Molecules, 2020 Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible ...
Ashraf S. A. El-Sayed +6 more
doaj +1 more source
Downstream reactions and engineering in the microbially reconstituted pathway for Taxol [PDF]
, 2016 Taxol (a trademarked product of Bristol-Myers Squibb) is a complex isoprenoid natural product which has displayed potent anticancer activity. Originally isolated from the Pacific yew tree (Taxus brevifolia), Taxol has been mass-produced through processes
Jiang, Ming +2 more
core +1 more source
Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps [PDF]
, 2019 This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic ...
Caretto, Sofia +11 more
core +1 more source
BMC Genomics, 2020 Background Taxus cells are a potential sustainable and environment-friendly source of taxol, but they have low survival ratios and slow grow rates. Despite these limitations, Taxus callus cells induced through 6 months of culture contain more taxol than ...
Ying Chen +7 more
doaj +1 more source