Results 21 to 30 of about 327,793 (259)
Transcriptome and Metabolome Analyses of Taxus chinensis var. mairei Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis [PDF]
PlantsTaxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear.
Luyuan Jiang +9 more
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Frontiers in Microbiology, 2019 Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The
Ingy I. Abdallah +5 more
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Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide [PDF]
Biotechnology for Biofuels and BioproductsTaxol serves as an efficient natural anticancer agent with extensive applications in the treatment of diverse malignancies. Although advances in synthetic biology have enabled the de novo synthesis of taxol precursors in various microbial chassis, the ...
Jialing Zhong +6 more
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Cytochrome P450 oxygenases of Taxol biosynthesis [PDF]
Phytochemistry Reviews, 2006 Cytochrome P450 monooxygenases play a prominent role in the biosynthesis of the diterpenoid anticancer drug Taxol, as they appear to constitute about half of the 19 enzymatic steps of the pathway in yew (Taxus) species. A combination of classical biochemical and molecular methods, including cell-free enzyme studies and differential-display of mRNA ...
Rüdiger Kaspera, Rodney Croteau
openalex +3 more sources
Chemistry & Biology, 2004 Biosynthesis of the anticancer drug Taxol in yew species involves eight cytochrome P450-mediated oxygenations and four coenzyme A-dependent acylations of the diterpenoid core. A family of cytochrome P450 genes, obtained from a yew cell cDNA library, were functionally expressed and screened with taxusin (taxa-4(20),11(12)-dien-5 alpha,9 alpha,10 beta,13
MyDoanh Chau +3 more
+5 more sources
High-yield biosynthesis of taxol precursors in engineered Escherichia coli [PDF]
Science-Business eXchange, 2010 openalex +2 more sources
The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites. [PDF]
Nat Prod Rep, 2012 Guerra-Bubb J, Croteau R, Williams RM.
europepmc +3 more sources
Enhancement of Paclitaxel's Anticancer Efficacy in Thyroid Cancer by Isodeoxyelephantopin Through Modulation of Oxidative Stress. [PDF]
Food Sci NutrIsodeoxyelephantopin (IDET) enhances paclitaxel sensitivity in thyroid cancer by promoting ROS‐mediated apoptosis through inhibition of the p62‐Keap1‐Nrf2 antioxidant pathway. The combination treatment suppresses tumor growth and metastasis with minimal toxicity, suggesting IDET as a safe and effective chemosensitizer to improve Taxol‐based therapy ...
Cong W, Sun J, Hao Z, Gong M.
europepmc +2 more sources