Results 31 to 40 of about 28,043 (224)

Classification of Transcription Boundary-Associated RNAs (TBARs) in Animals and Plants [PDF]

Frontiers in Genetics, 2018
There is increasing evidence suggesting the contribution of non-coding RNAs (ncRNAs) to the phenotypic and physiological complexity of organisms. A novel ncRNA species has been identified near the transcription boundaries of protein-coding genes in eukaryotes, bacteria, and archaea.
Yu, Dongliang, Ma, Xiaoxia, Zuo, Ziwei, Wang, Huizhong, Meng, Yijun   +4 more
openaire   +3 more sources

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Plasma thiobarbituric acid reactive substances predicts survival in chemotherapy naïve patients with metastatic urothelial carcinoma

Translational Oncology, 2021
Oxidative stress plays a significant role in development and progression of cancer, including urothelial carcinomas. TBARS (Thiobarbituric acid reactive substances) represents a marker of oxidative stress increased in various diseases.
Jan Slopovsky, Jarmila Kucharska, Jana Obertova, Michal Mego, Katarina Kalavska, Silvia Cingelova, Daniela Svetlovska, Anna Gvozdjakova, Samuel Furka, Patrik Palacka   +9 more
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Changes in quality and antioxidant properties of dry sausages produced by type and dosis of paprika

Czech Journal of Food Sciences, 2004
The objective of the study was to evaluate the effect of the highest doses of paprika and the different percentage of hot paprika on curing process of dry sausage "Chorizo Zamorano" evaluating texture, colour and antioxidant properties. Four types of dry
I. Revilla, A. M Vivar-Quintana
doaj   +1 more source

Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post‐traumatic stress disorder

Animal Models and Experimental Medicine, EarlyView.
Single prolonged stress (SPS) induces post‐traumatic stress disorder (PTSD)‐like neuropathology characterized by oxidative stress, neuroinflammation, astrocytic reactivity, neuronal damage, and reduced neurotrophic support in the hippocampus, amygdala, and prefrontal cortex. Hesperidin counteracts these effects by attenuating lipid peroxidation and pro‐
Godson Emeka Anyanwu, Ogan Christopher Akanaku, Augustine Oviosun, Precious E. Ekwueme, Paul Anyiom Odey, Chima Paul Okechukwu Ugwu, Chinyere Nkemjika Anyanwu   +6 more
wiley   +1 more source

Oxidative stress and antioxidant defences generated by solar UV in a Subantarctic marine phytoflagellate

Scientia Marina, 2005
The reduction of the Antarctic stratospheric ozone resulted in significant increases in ultraviolet B radiation (UV-B, 280-320 nm) reaching the surface of the ocean.
Marcelo Pablo Hernando, Gabriela Fabiana Malanga, Gustavo Adolfo Ferreyra   +2 more
doaj   +1 more source

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, EarlyView.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source

TBARS and microbial growth predicative models of pork sausage stored at different temperatures

Czech Journal of Food Sciences, 2015
Kinetic models were developed for quality changes of emulsified pork sausages to predict the TBARS (2-thiobarbituric acid reactive substance) and TVC (total viable counts) changes at different temperatures during storage.
Anna KACZMAREK, Renata CEGIELSKA-RADZIEJEWSKA, Tomasz SZABLEWSKI, Jan ZABIELSKI   +3 more
doaj   +1 more source

A modified D‐galactose‐induced aging rat model with low‐dose intraperitoneal ozone: Redox, functional, and skin outcomes

Animal Models and Experimental Medicine, EarlyView.
Male Wistar rats were subjected to d‐galactose‐induced aging, with or without intermittent low‐dose intraperitoneal ozone administration, and evaluated over 8 weeks for redox status and physical performance, including physical health score, morbidity proportion, body weight, muscle strength, hair regrowth, and skin outcome.
Isabella Kurnia Liem, Raisa Nauli, Firda Asma’ul Husna, Sasanthy Kusumaningtyas, Deswaty Furqonita, Ferbian Milas Siswanto, Soegianto Ali   +6 more
wiley   +1 more source