Results 131 to 140 of about 146,987 (295)

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Colon cancer survival prediction from gland shapes within histology slides using deep learning

Journal of Integrative Bioinformatics
This study investigates the application of deep learning techniques for segmenting glands in histopathological images of colorectal cancer. We trained two convolutional neural network models, U-Net and DCAN, on a combination of the GlaS and CRAG datasets
Gedeon Rawan, Nagar Atulya
doaj   +1 more source

A3-BL-HNeck-TCGA-CORDA-R3D-LeakyFree-Flux-bounds.gms is to set up the lower and upper bounds for fluxes. from Fuzzy optimization for identifying anti-cancer targets with few side effects in constraint-based models of head and neck cancer

, 2022
Feng‐Sheng Wang, Peirong Chen, Ting‐Yu Chen, Hao-Xiang Zhang   +3 more
openalex   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Assessing the predictive power of immune microenvironment-related genes and clinical immune-inflammatory parameters in breast cancer

All Life
This study aims to improve breast cancer (BC) prognostic biomarker detection, overcoming current methods’ complexity, high – cost, and low – precision issues.
Shangyi Lu, Shun Liang, Fucai Chen, Jianyuan Meng, Junwei Chen, Yi Lu, Gangjian Zhu   +6 more
doaj   +1 more source

Integrated analysis of lymphocyte infiltration-associated lncRNA for ovarian cancer via TCGA, GTEx and GEO datasets

, 2020
Meijing Wu, Xiaobin Shang, Yue Sun, Jing Wu, Guoyan Liu   +4 more
openalex   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Increased MPO in Colorectal Cancer Is Associated With High Peripheral Neutrophil Counts and a Poor Prognosis: A TCGA With Propensity Score-Matched Analysis

, 2022
Meilin Weng, Ying Yue, Dan Wu, Changming Zhou, Miaomiao Guo, Caihong Sun, Qingwu Liao, Minli Sun, Di Zhou, Changhong Miao   +9 more
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

<p>Biological and Clinical Significance of GATA3 Detected from TCGA Database and FFPE Sample in Bladder Cancer Patients</p>

, 2020
Chenglu Wang, Shuang Yang, Jin Lü, Guangcheng Dai, Yao Qiu, Xiang Han, Yongsheng Zhang, Xiaolong Liu, Boxin Xue   +8 more
openalex   +2 more sources