Results 31 to 40 of about 184,470 (334)

The integration of single-cell sequencing, TCGA, and GEO data analysis revealed that PRRT3-AS1 is a biomarker and therapeutic target of SKCM

Frontiers in Immunology, 2022
Introduction Skin cutaneous melanoma (SKCM) is the world’s fourth deadliest cancer, and advanced SKCM leads to a poor prognosis. Novel biomarkers for SKCM diagnosis and prognosis are urgently needed.
Wancong Zhang, Xuqi Xie, Zijian Huang, Xiaoping Zhong, Yang Liu, K. Cheong, Jianda Zhou, Shijie Tang   +7 more
semanticscholar   +1 more source

Morphometic analysis of TCGA glioblastoma multiforme [PDF]

BMC Bioinformatics, 2011
AbstractBackgroundOur goals are to develop a computational histopathology pipeline for characterizing tumor types that are being generated by The Cancer Genome Atlas (TCGA) for genomic association. TCGA is a national collaborative program where different tumor types are being collected, and each tumor is being characterized using a variety of genome ...
Frederick L. Baehner, Joe W. Gray, Joe W. Gray, Hang Chang, Gerald V. Fontenay, Ju Han, Paul T. Spellman, Paul T. Spellman, Ge Cong, Bahram Parvin   +9 more
openaire   +5 more sources

Reclassification of TCGA Diffuse Glioma Profiles Linked to Transcriptomic, Epigenetic, Genomic and Clinical Data, According to the 2021 WHO CNS Tumor Classification

International Journal of Molecular Sciences, 2022
In 2021, the fifth edition of the WHO classification of tumors of the central nervous system (WHO CNS5) was published. Molecular features of tumors were directly incorporated into the diagnostic decision tree, thus affecting both the typing and staging ...
G. Zakharova, V. Efimov, Mikhail M. Raevskiy, P. Rumiantsev, Alexander Gudkov, O. Belogurova-Ovchinnikova, M. Sorokin, A. Buzdin   +7 more
semanticscholar   +1 more source

CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer

Scientific Reports, 2021
Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple Negative Breast Cancer (TNBC) is associated with better prognosis. However, the molecular mechanisms underlying these immune cell differences are not well delineated.
K. E. Craven, Yesim Gökmen-Polar, S. Badve   +2 more
semanticscholar   +1 more source

Increased MPO in Colorectal Cancer Is Associated With High Peripheral Neutrophil Counts and a Poor Prognosis: A TCGA With Propensity Score-Matched Analysis

Frontiers in Oncology, 2022
Background Myeloperoxidase (MPO) has been demonstrated to be a local mediator of inflammation in tissue damage in various inflammatory diseases. Given its controversial effect on colorectal cancer (CRC), there has been growing interest in investigating ...
M. Weng, Ying Yue, Dan Wu, Changming Zhou, Miaomiao Guo, Caihong Sun, Qingwu Liao, Minli Sun, D. Zhou, C. Miao   +9 more
semanticscholar   +1 more source

Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer

BMC Cancer, 2021
Background Liver cancer is the sixth most commonly diagnosed cancer and the fourth most common cause of cancer death. The purpose of this work is to find new diagnostic biomarkers or prognostic biomarkers and explore the biological functions related to ...
Shiyong Gao, Jian Gang, M. Yu, G. Xin, Huixin Tan   +4 more
semanticscholar   +1 more source

The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets

Frontiers in Genetics, 2022
Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. However, its specific role and mechanism with immune infiltrates in gastric cancer are still unclear ...
Lulu Zhao, Wan-Peng Wang, Penghui Niu, Xiaoyi Luan, Dongbing Zhao, Yingtai Chen   +5 more
semanticscholar   +1 more source

T2–FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project

Clinical Cancer Research, 2017
Sohil H. Patel, Laila Poisson, Daniel J. Brat, Yueren Zhou, Lee Cooper, Matija Snuderl, Cheddhi Thomas, Ana M. Franceschi, Brent Griffith, Adam E. Flanders, John G. Golfinos, S. Andrew, Rajan Jain   +12 more
openalex   +2 more sources

The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions

Cancers, 2021
Simple Summary The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) is a recently developed tool to identify four distinct molecular subgroups of endometrial cancer. Patients identified as Polymerase Epsilon exonuclease domain mutated
Matthias Alexa, A. Hasenburg, M. Battista   +2 more
semanticscholar   +1 more source

Biomarkers of Tumor Heterogeneity in Glioblastoma Multiforme Cohort of TCGA [PDF]

Cancers, 2023
Tumor Whole Slide Images (WSI) are often heterogeneous, which hinders the discovery of biomarkers in the presence of confounding clinical factors. In this study, we present a pipeline for identifying biomarkers from the Glioblastoma Multiforme (GBM) cohort of WSIs from TCGA archive. The GBM cohort endures many technical artifacts while the discovery of
Garrett Winkelmaier, Brandon Koch, Skylar Bogardus, Alexander D. Borowsky, Bahram Parvin   +4 more
openaire   +3 more sources