Results 81 to 90 of about 146,987 (295)

An integrated prognostic model of nuclear-encoded mitochondrial gene signature and clinical information for hepatocellular carcinoma

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To establish a prognostic model for the overall survival (OS) of hepatocellular carcinoma (HCC) based on mitochondrial genes and clinical information.Methods·The gene expression and the clinical data of 369 HCC patients and 50 controls with ...
Kedeerya Aishanjiang, FU Yi, LAI Donglin, WU Hailong, GONG Wei   +4 more
doaj   +1 more source

M1 macrophage-related prognostic model by combining bulk and single-cell transcriptomic data in NSCLC [PDF]

Exploration of Medicine
Aim: Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common subtype. Despite recent advancements in diagnostics and therapies, only a small percentage of patients benefit from ...
Zhe Liu, Fang Liu, Olutomilayo Olayemi Petinrin, Muhammad Toseef, Nanjun Chen, Zhongxu Zhu, Ka-Chun Wong   +6 more
doaj   +1 more source

TCGA-HNSC NIFTI Test Data

, 2021
Phillip Chlap
openalex   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

TCGA molecular classification in endometriosis-associated ovarian carcinomas: Novel data on clear cell carcinoma

, 2022
Jonna Similä-Maarala, Piret Soovares, Annukka Pasanen, Terhi Ahvenainen, Pia Vahteristo, Ralf Bützow, Heini Lassus   +6 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Development and Validation of an Immune-Related Gene Pair Signature in Skin Cutaneous Melanoma

Clinical, Cosmetic and Investigational Dermatology, 2020
Ran Xie,1,* Suwei Dong,2,* Jie Jiang,3 Conghui Yang,1 Lanjiang Li,4 Sheng Zhao,1 Yunlei Li,3 Chun Wang,1 Shujuan Li,1 Yanbin Xiao,2 Long Chen1 1PET/CT Center, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Cancer ...
Xie R, Dong S, Jiang J, Yang C, Li L, Zhao S, Li Y, Wang C, Li S, Xiao Y, Chen L   +10 more
doaj  

Promising markers of CIMP+ colon tumors identified on the basis of TCGA data analysis

Вавиловский журнал генетики и селекции, 2018
CIMP+ (CpG­Island Methylator Phenotype) tumors are characterized by dense methylation of promoter CpG islands of many genes at once and represent a separate group of malignant neoplasms of the colon.
G. S. Krasnov, A. D. Beniaminov, R. A. Tychko, G. A. Puzanov, R. O. Novakovskiy, A. V. Kudryavtseva, A. A. Dmitriev   +6 more
doaj   +1 more source

The TCGA dataset of SKCM and GTEx dataset of skin tissue.

, 2023
Chuson Wilis
openalex   +1 more source