Results 111 to 120 of about 272,710 (333)

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Novel NHEJ1 pathogenic variant linked to severe combined immunodeficiency, microcephaly, and abnormal T and B cell receptor repertoires

Frontiers in Pediatrics, 2022
BackgroundDuring the process of generating diverse T and B cell receptor (TCR and BCR, respectively) repertoires, double-strand DNA breaks are produced.
Shirly Frizinsky, Shirly Frizinsky, Erez Rechavi, Erez Rechavi, Ortal Barel, Yu Nee Lee, Yu Nee Lee, Amos J. Simon, Amos J. Simon, Atar Lev, Atar Lev, Tali Stauber, Tali Stauber, Tali Stauber, Etai Adam, Raz Somech, Raz Somech, Raz Somech   +17 more
doaj   +1 more source

Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy [PDF]

, 2015
HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology, and response to antiretroviral treatment - and how best to monitor them ...
Best, K, Chain, B, Friedman, N, Gray, ER, Heather, JM, Noursadeghi, M, Oakes, T, Roe, JK, Thomas, N   +8 more
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]

, 2016
The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc, Cosmo Di, Donnac, GISMONDI, Angela, Isabella, Sperdutid, Ornella, Franzesea, SANTONI, Angela, STABILE, MARIA HELENA, Virginia, Ferraresie   +7 more
core   +1 more source

The partitioning of TCR repertoires by thymic selection

Journal of Experimental Medicine
αβ T cells are critical components of the adaptive immune system; they maintain tissue and immune homeostasis during health, provide sterilizing immunity after pathogen infection, and are capable of eliminating transformed tumor cells. Fundamental to these distinct functions is the ligand specificity of the unique antigen receptor expressed on each ...
Wan-Lin Lo, Eric S. Huseby
openaire   +2 more sources

Clonotype Tracking of TCR Repertoires during Chronic Virus Infections

Virology, 2002
Human viral infections such as HIV and EBV typically evoke a strong and diverse CD8(+) T cell response. Relatively little is known about the extent to which TCR repertoire evolution occurs during viral infection or how repertoire evolution affects the efficacy of the CD8(+) T cell response.
Cohen, George B., Islam, Sabina A., Noble, Miriam S., Lau, Christina, Brander, Christian, Altfeld, Marcus A., Rosenberg, Eric S., Schmitz, Jörn E., Cameron, Thomas O., Kalams, Spyros A.   +9 more
openaire   +2 more sources

TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis

EBioMedicine, 2019
Background Ankylosing spondylitis (AS) is a chronic inflammatory disease with worldwide high prevalence. Although AS is strongly associated with HLA-B27 MHC-I antigen presentation, the role played by αβ T cells in AS remains elusive.
Ming Zheng, Xin Zhang, Yinghui Zhou, Juan Tang, Q. Han, Yang Zhang, Qingshan Ni, Gang Chen, Q. Jia, Haili Yu, Siqi Liu, Elizabeth Robins, Ning Jiang, Y. Wan, Qi-jing Li, Zhi-Nan Chen, P. Zhu   +16 more
semanticscholar   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Linking Microbiome Diversity and Immune Profiles in Ethiopian Patients With Cervical Cancer

JCO Global Oncology
PURPOSEThis study investigates the interplay between T-cell receptor (TCR) immune characteristics and microbiome profiles to explore the relationship between immune diversity and microbial composition in cervical samples from Ethiopia.METHODSCervical ...
Kyoko Yoshida-Court, Brhanu Teka, Tatiana Cisneros Napravnik, Tatiana Karpinets, Molly B. El Alam, Ededia Firdawoke, Zewditu Chanyalew, Adane Mihret, Adamu Addissie, Muluken Gizaw, Jessica Lan, Cara Haymaker, Dzifa Y. Duose, Rajyalakshmi Luthra, Lauren E. Colbert, Anuja Jhingran, Eva Johanna Kantelhardt, Andreas M. Kaufmann, Tamrat Abebe, Ann H. Klopp   +19 more
doaj   +1 more source