Results 201 to 210 of about 272,710 (333)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, Volume 13, Issue 18, 27 March 2026.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

TCR Repertoire Analysis Reveals Public Motifs with High Probability for Allergen Epitope Specificity [PDF]

, 2019
Neal P. Smith, Bert Ruiter, Navneet K. Virk Hundal, Huong Tang, Yamini V. Virkud, Sarita U. Patil, Wayne G. Shreffler   +6 more
openalex   +1 more source

VJ Segment Usage of TCR-Beta Repertoire in Monozygotic Cystic Fibrosis Twins

, 2021
Sebastian Fischer, Frauke Stanke, Burkhard Tümmler   +2 more
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia. [PDF]

Front Immunol, 2023
Pospiech M, Tamizharasan M, Wei YC, Kumar AMS, Lou M, Milstein J, Alachkar H.   +6 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

ImmunTraCkeR® as a reliable TCR repertoire profiling tool to understand immune response and to explore immunotherapy biomarkers [PDF]

, 2013
Isabelle Tanneau, Audrey Nondé, Anaïs Courtier, Gilles Parmentier, Marlène Noël, Audrey Grivès, Solène Perez, Nadia Plantier, Jean-François Mouret, Orchidée Filipe‐Santos, Manuarii Manuel   +10 more
openalex   +1 more source

Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition

BioEssays, Volume 48, Issue 3, March 2026.
Along with peptides, MHC polymorphisms allosterically tune peptide energy landscapes, altering conformational dynamics and T cell receptor recognition. This dynamic allostery mechanism explains how subtle polymorphic differences drive differential immune specificity across individuals and populations.
Bassant Eldaly, Brian M. Baker
wiley   +1 more source

TCR β CDR3 Repertoire Signatures in Paired PBMC and BALF From Children With Mycoplasma pneumoniae Pneumonia

Xinzhu Liu
openalex   +2 more sources

Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq. [PDF]

Sci Rep, 2023
Heimli M, Tennebø Flåm S, Sagsveen Hjorthaug H, Bjørnstad PM, Chernigovskaya M, Le QK, Tekpli X, Greiff V, Lie BA.   +8 more
europepmc   +1 more source