Results 211 to 220 of about 272,710 (333)

Adaptive Genetic Variation in Black‐and‐White Snub‐Nosed Monkeys (Rhinopithecus bieti): Low Diversity and the Role of Balancing Selection

Ecology and Evolution, Volume 16, Issue 3, March 2026.
We investigated the adaptive genetic diversity within a population of Rhinopithecus bieti using amplicon sequencing. From 47 individuals, we identified 16 MHC class I sequences, revealing a low level of adaptive genetic variation. Although evidence for balancing selection, including positive selection and trans‐species polymorphism, was observed, these
Fei Long, Mei‐Jing Ying, Tian‐Qi Shi, Paul A. Garber, Ru‐Liang Pan, Jian‐Dong Lai, Zhi‐Pang Huang, Bao‐Guo Li, Pei Zhang   +8 more
wiley   +1 more source

Non‐cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC‐E Restricted CD8 T Cell Population

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Mouse Qa1b‐restricted T cells show promiscuous requirements for positive selection. Using in vivo tetramer enrichment, in vitro APC engineering, and in vitro thymocyte stimulation, we demonstrate that a Qa1b‐restricted T cell population can be selected by both Qa1b and H2‐T11, and depends on non‐cognate CD8‐MHC I binding.
Xiaokun Yang, Melissa A. Colden, Rachel Coombs, Kathya Arana, Dan Tran, Michael Manoharan Valerio, Ellen A. Robey, Laurent Coscoy   +7 more
wiley   +1 more source

Unique features of the TCR repertoire of reactivated memory T cells in the experimental mouse tumor model. [PDF]

Comput Struct Biotechnol J, 2023
Kalinina A, Persiyantseva N, Britanova O, Lupyr K, Shagina I, Khromykh L, Kazansky D.   +6 more
europepmc   +1 more source

Analyzing the CDR3 Repertoire with respect to TCR—Beta Chain V-D-J and V-J Rearrangements in Peripheral T Cells using HTS [PDF]

, 2016
Long Ma, Liwen Yang, Bin Shi, Xiaoyan He, Aihua Peng, Yuehong Li, Teng Zhang, Suhong Sun, Rui Ma, Xinsheng Yao   +9 more
openalex   +1 more source

Supplementary Table S2 from TCR Repertoire Diversity of Peripheral PD-1⁺CD8⁺ T Cells Predicts Clinical Outcomes after Immunotherapy in Patients with Non–Small Cell Lung Cancer

, 2023
Jiefei Han, Jianchun Duan, Hua Bai, Yuqi Wang, Rui Wan, Xin Wang, Si Chen, Yanhua Tian, Di Wang, Kailun Fei, Zhuoran Yao, Shuhang Wang, Zhimin Lu, Zhijie Wang, Jie Wang   +14 more
openalex   +1 more source

Body composition predicts poor outcomes and reveals immunometabolic dysfunction via single‐cell profiling in anti‐BCMA CAR T‐treated myeloma

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of relapsed or refractory multiple myeloma (RRMM), yet outcomes remain heterogenous. The prognostic role of body composition in this context is unknown. We retrospectively analyzed 108 RRMM patients treated with anti‐B‐cell maturation antigen (BCMA) CAR T‐cell therapy.
Thomas C. Wiemers, Michael Rade, Nora Grieb, Maximilian Ferle, Tihomir Dermendzhiev, David Fandrei, Patrick Born, Luise Fischer, Sabine Seiffert, Anja Grahnert, Maik Friedrich, Ronny Baber, Markus Kreuz, Klaus H. Metzeler, Marco Herling, Carmen D. Herling, Madlen Jentzsch, Georg‐Nikolaus Franke, Andreas Boldt, Thomas Neumuth, Urvi A. Shah, Ulrike Köhl, Kristin Reiche, Timm Denecke, Uwe Platzbecker, Vladan Vučinić, Hans‐Jonas Meyer, Maximilian Merz   +27 more
wiley   +1 more source

A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity. [PDF]

J Clin Immunol, 2023
Assing K, Jørgensen SE, Sandgaard KS, De Keukeleere K, B-Hansen M, Petersen MS, Hartling UB, Vaal TMK, Nielsen C, Jakobsen MA, Watt E, Adams S, Hao Q, Fagerberg C, Mogensen TH, Mogensen TH.   +15 more
europepmc   +1 more source

T cell development in the chicken [PDF]

, 1994
Bernot, Bucy, Bucy, C.H. CHEN, Chan, Char, Chen, Chen, Chen, Chen, Chen, Cihak, Cihak, Cihak, Coltey, Coltey, Cooper, Davidson, Dunon, George, Göbel, Haas, Kasahara, Lahti, M.D. COOPER, McCormack, Quere, Schiffer, Sowder, T. KUBOTA, T.W.F. GÖBEL, Tjoelker, Veillette, Wyss-Coray   +33 more
core   +1 more source

New Perspective: Bench to Bedside Evidence of the Role of CD8+ T Cells in Alzheimer's Disease

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
Emerging evidence highlights a previously underappreciated role of CD8+ T cells in Alzheimer's disease (AD). Beyond amyloid‐β and tau pathology, CD8+ T‐cell subsets infiltrate the central nervous system and exhibit functional heterogeneity. Cytotoxic effector CD8+ T cells may exacerbate neuroinflammation and neuronal injury, whereas regulatory or ...
Yong Peng, Shun‐yu Yao, Si‐Liang Wu, Huan Yang, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Xu‐hui Kang, Dai‐yi Jiang   +10 more
wiley   +1 more source

The thymic cortical epithelium determines the TCR repertoire of IL ‐17‐producing γδT cells

, 2015
Takeshi Nitta, Ryunosuke Muro, Yukiko Shimizu, Sachiko Nitta, Hiroyo Oda, Yuki Ohte, Motohito Goto, Rieko Yanobu‐Takanashi, Tomoya Narita, Hiroshi Takayanagi, Hisataka Yasuda, Tadashi Okamura, Shigeo Murata, Harumi Suzuki   +13 more
openalex   +2 more sources