Results 241 to 250 of about 272,710 (333)

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Divergent outcomes of anti-PD-L1 treatment coupled with host-intrinsic differences in TCR repertoire and distinct T cell activation states in responding versus non-responding tumors

, 2022
Jessy John, Rachel A. Woolaver, Vince Popolizio, Samantha M. Y. Chen, Huaibin Ge, Alexandra L. Krinsky, Monika Vashisht, Yonatan Kramer, Zhangguo Chen, Jing Wang   +9 more
openalex   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

Pre-treatment peripheral blood TCR repertoire as a predictor of response in patients with NSCLC treated with immunochemotherapy. [PDF]

BMC Cancer
Yang Y, Jiang HY, Li Y, Wu F, Chen ZY, Zheng GP, Su WZ, Wang HL, Pang M.   +8 more
europepmc   +1 more source

TCR repertoire and transcriptional signatures of circulating tumour-associated T cells facilitate effective non-invasive cancer detection. [PDF]

Clin Transl Med, 2022
Ji F, Chen L, Chen Z, Luo B, Wang Y, Lan X.   +5 more
europepmc   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

MBP 85-99-SPECIFIC TCR REPERTOIRE IN DRB1*15 PATIENTS AFFECTED BY MULTIPLE SCLEROSIS

, 2013
Gabriele Di Sante, Simona Rolla, Patanella Agata Katia, Paolini Luisa, Mariagrazia Valentini, Nicol� Chiara, Giuseppe Migliara, Alessia Piermattei, Novelli Francesco, Massimiliano Mirabella, Ria Francesco   +10 more
openalex   +1 more source

Data from Transient Depletion of CD4⁺ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer

, 2023
Hiroyasu Aoki, Satoshi Ueha, Shigeyuki Shichino, Haru Ogiwara, Kohei Shitara, Manami Shimomura, Toshihiro Suzuki, Tetsuya Nakatsura, Makiko Yamashita, Shigehisa Kitano, Sakiko Kuroda, Masashi Wakabayashi, Makoto Kurachi, Satoru Ito, Toshihiko Doi, Kouji Matsushima   +15 more
openalex   +1 more source

The Current Status of T Cell Receptor (TCR) Repertoire Analysis in Colorectal Cancer. [PDF]

Int J Mol Sci
Takahashi H, Hanaoka K, Wada H, Kojima D, Watanabe M.   +4 more
europepmc   +1 more source

Single-Cell-Based High-Throughput Ig and TCR Repertoire Sequencing Analysis in Rhesus Macaques. [PDF]

J Immunol, 2022
Walsh ES, Tollison TS, Brochu HN, Shaw BI, Diveley KR, Chou H, Law L, Kirk AD, Gale M, Peng X.   +9 more
europepmc   +1 more source