Results 71 to 80 of about 272,710 (333)

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

RAGs and Regulation of Autoantibodies [PDF]

, 2004
Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael, Jankovic, Mila, Nussenzweig, Michel C., Wardemann, ­Hedda, Yannoutsos, Nikos   +4 more
core   +1 more source

The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies

Frontiers in Immunology, 2020
Natalizumab (NTZ) and autologous hematopoietic stem cell transplantation (AHSCT) are two successful treatments for relapsing-remitting multiple sclerosis (RRMS), an autoimmune T-cell-driven disorder affecting the central nervous system that is ...
R. Amoriello, Victor Greiff, A. Aldinucci, E. Bonechi, A. Carnasciali, B. Peruzzi, A. Repice, A. Mariottini, R. Saccardi, B. Mazzanti, L. Massacesi, C. Ballerini   +11 more
semanticscholar   +1 more source

Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients

Journal of Translational Medicine, 2010
Several immunotherapeutic approaches rely on antigen-specific T-cells. Restrictions in the T-cell receptor (TCR) repertoire were reported as indicator of anti-tumor cytotoxic T-lymphocyte (CTL) response in various tumor entities.
Thiel Eckhard, Nüssler Natascha C, Busse Antonia, Wojtke Susanne, Fusi Alberto, Ochsenreither Sebastian, Keilholz Ulrich, Nagorsen Dirk   +7 more
doaj   +1 more source

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1

Cell Reports Medicine, 2020
Summary T cells use highly diverse receptors (TCRs) to identify tumor cells presenting neoantigens arising from genetic mutations and establish anti-tumor activity.
A. Poran, J. Scherer, M. Bushway, Rana H. Besada, Kristen N. Balogh, Amy Wanamaker, Reid Williams, Jasmina Prabhakara, P. Ott, S. Hu-Lieskovan, Z. Khondker, R. Gaynor, Michael S. Rooney, L. Srinivasan   +13 more
semanticscholar   +1 more source

Circulating gluten‐specific, but not CMV‐specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire

Clinical & Translational Immunology, 2020
Objectives Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T‐cell (Treg) populations is important for strategies aiming to re‐establish tolerance in autoimmune diseases. We studied circulating deamidated gluten‐epitope‐specific CD39+
Laura Cook, C Mee Ling Munier, Nabila Seddiki, Melinda Y Hardy, Robert P Anderson, John Zaunders, Jason A Tye‐Din, Anthony D Kelleher, David vanBockel   +8 more
doaj   +1 more source

The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

eLife, 2020
The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequencing
Peter C de Greef, Theres Oakes, Bram Gerritsen, Mazlina Ismail, James M Heather, Rutger Hermsen, Benjamin Chain, Rob J de Boer   +7 more
doaj   +1 more source

Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage. [PDF]

PLoS ONE, 2012
Islet transplantation provides a "cure" for type 1 diabetes but is limited in part by recurrent autoimmunity mediated by β cell-specific CD4(+) and CD8(+) T cells.
Ramiro Diz, Alaina Garland, Benjamin G Vincent, Mark C Johnson, Nicholas Spidale, Bo Wang, Roland Tisch   +6 more
doaj   +1 more source

Assessing T cell clonal size distribution: a non-parametric approach

, 2014
Clonal structure of the human peripheral T-cell repertoire is shaped by a number of homeostatic mechanisms, including antigen presentation, cytokine and cell regulation.
Bolkhovskaya, O. V., Ivanchenko, M. V., Zorin, D. Yu.   +2 more
core   +2 more sources