Results 161 to 170 of about 95,928 (301)

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina. [PDF]

Elife
Liao B, Lyu C, Jiang Y, Liu S, Wong W, Zhang J, Tsang H, Xie J, Chen L, Zhang Q, Xiong W.   +10 more
europepmc   +1 more source

Temporal Density Theory (TDT)

Temporal Density Theory (TDT) proposes that time is not an external parameter but an emergent property of feedback and coherence across physical, cognitive, social, digital, and cosmic systems.By defining temporal density (ρₜ) as the ratio between energetic intensity and informational feedback, TDT unifies relativity, thermodynamics, and neuroscience ...
openaire   +1 more source

Volatile Additives Engineering: A Trustworthy Morphology Control Strategy in Non‐Fullerene Organic Solar Cells

Advanced Science, EarlyView.
In this review, the classification and development history of the volatile solid and solvent additives are comprehensively summarized, the underlying mechanisms of morphology optimization are discussed, and a summary of volatile additive‐induced improvements in interfacial layer performance is provided.
Jianqiang Qin, Zhiqin Lai, Jiang‐Ling Shi, Zheng Xiao, Yuwei Duan, Zhiping Hu, Juan Du, Qiang Peng   +7 more
wiley   +1 more source

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity. [PDF]

Nat Commun
Illendula A, Hewett CK, Hayata Y, Strathearn LS, He G, Carballo-Botinas L, Navas-Sanz S, Niqui-Capdevila M, Garcia-Santos A, Bernabé-Pérez R, Bustillo-Bustos A, Mikoyan A, Helm E, Gonzalez-Sorribes M, de Prisco N, Das A, Zhang Y, Rossell D, Slifker M, Akizu N, Sun B, Font-Burgada J.   +21 more
europepmc   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Análisis de los servicios interactivos que ofrece la TDT como servicio público a partir del ejemplo de Alcázar Digital TDT

Derecom
Cuando se lanzó la TDT se dudó si la televisión continuaría como servicio público. La TDT suponía evitar la brecha digital y acercar a la ciudadanía a la alfabetización tecnológica.
Fernando Peinado-y-Miguel, Betsabé Alhambra-Molina   +1 more
doaj  

Visualizing α-synuclein pathology in live brain: A new platform for Parkinson's disease research. [PDF]

Clin Transl Med
Yu M, Cao P.
europepmc   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Integrative analysis of the embryonic origin of adult neural stem cells in forebrain subventricular zones. [PDF]

Natl Sci Rev
Wu H, Tang K, Xu R, Li T, Liang K, Wang X, Huang D, Yang Y, Yin Y, Xie J, Li C, Liu X, Bai QR, Wang C, Shen Q, Gao S.   +15 more
europepmc   +1 more source