Results 171 to 180 of about 95,928 (301)

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Factors Contributing to Improved Bone Mineral Density in Patients With Transfusion-Dependent Thalassemia. [PDF]

Kaohsiung J Med Sci
Hsu CY, Hsiao HP, Chiou SS, Lin PC, Liao YM, Hsu WY, Wang TH, Wang SY.   +7 more
europepmc   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

A yolk sac-derived hepatic γδ T cell subpopulation develops in a hematopoietic stem cell- and thymus-independent manner. [PDF]

Protein Cell
Chen Y, Wang C, Huang K, You G, Liu B, Lan Y.   +5 more
europepmc   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Potansiyel Girişimciler İçin Fırsatlar: Türk Devletleri Teşkilatı (TDT) Üye Ülkeleri

Türkiye Cumhuriyeti Dış İşleri Bakanlığı’nın yürütmekte olduğu uluslararası kuruluşlarla iş birlikleri kapsamında, Türk Devletleri Teşkilatı (TDT) yer almaktadır.
KORKMAZ, Hafize Ufuk
core   +1 more source

Bisphosphonate therapy for thalassemia-related bone disorders in children and young adults: a systematic review. [PDF]

Ann Pediatr Endocrinol Metab
Mangkuliguna G, Handisurya IWA, Adrianto N.   +2 more
europepmc   +1 more source

Electron Transport in Quantum Dot Light‐Emitting Diodes

Advanced Electronic Materials, EarlyView.
This work reveals that electron transport in core/multi‐shell quantum dots is severely hindered by traps located at the core‐shell interface. These traps follow a Gaussian energy distribution with a density of approximately 1023 m−3 and a common energy level of 4.0 eV below the vacuum level.
Shuxin Li, Wenxin Lin, Min Zheng, Xiongfeng Lin, Yulin Guo, Longjia Wu, Quan Niu, Paul W. M. Blom, Yuguang Ma   +8 more
wiley   +1 more source

Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function. [PDF]

EMBO J
Yang J, Bandyopadhyay S, Wang D, Gonzalez E, Chen Y, Bhupana JN, Pellon-Cardenas O, Park H, Balasubramanian I, Bianchi-Smak J, Zhang X, Wei Z, Bonder EM, Verzi MP, Etchegaray JP, Gao N.   +15 more
europepmc   +1 more source