Results 31 to 40 of about 95,928 (301)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The Transmission Disequilibrium/Heterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases

Journal of Probability and Statistics, 2012
In linkage analysis for mapping genetic diseases, the transmission/disequilibrium test (TDT) uses the linkage disequilibrium (LD) between some marker and trait loci for precise genetic mapping while avoiding confounding due to population stratification ...
Jing Han, Yongzhao Shao
doaj   +1 more source

Terminal Deoxynucleotidyl Transferase (TdT) Inhibiti on of Cord Blood Derived B and T Cells Expansion [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Terminal deoxynucleotidyl transferase(TdT) is a DNA polymerase that is present in immature pre-B and pre-T cells. TdT inserts N-nucleotides to the V (D) J gene segment during rearrangements of genes, therefore, it plays a vital role in the ...
Sanaz Gholami, Seyede Momeneh Mohammadi, Aliakbar Movasaghpour Akbari, Ali Abedelahi, Alireza Alihemmati, Shirin Fallahi, Hojjatollah Nozad Charoudeh   +6 more
doaj   +1 more source

UbcH5a or UbcH6 directly binds to TdT and E3-independently ubiquitylates TdT in vitro.

, 2012
(A) Ten E2 enzymes were subjected to SDS-PAGE and stained by CBB. (B) Binding between TdT and E2 enzymes in vitro. Ten purified recombinant His-E2 enzymes were incubated with GST- (lane 2), GST-TdT (lane 3) bound Glutathione Sepharose 4B.
Takuro Matsumoto (152830), Tomoyoshi Kato (152813), Sachiko Ando (152827), So Maezawa (152806), Kotaro Koiwai (152844), Osamu Koiwai (152848), Takahide Hayano (152836), Masahiro Suzuki (152839), Yoshihiro Nishiyama (152821), Rie Fukushima (152809), Toyofumi Matsushita (152811), Yoshiki Takagaki (152817), Kousuke Kouda (152833)   +12 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Family-Based Analysis Combined with Case–Controls Study Implicate Roles of PCNT in Tourette Syndrome

Neuropsychiatric Disease and Treatment, 2020
Wenmiao Liu, 1, 2,* Yixia Guo, 3,* Xiumei Liu, 4 Ru Zhang, 1, 2 Jicheng Dong, 5 Hao Deng, 6 Fan He, 7 Fengyuan Che, 8 Shiguo Liu, 1, 2 Mingji Yi 9 1Medical Genetics Department, The Affiliated Hospital of Qingdao University, Qingdao, People’s ...
Liu W, Guo Y, Liu X, Zhang R, Dong J, Deng H, He F, Che F, Liu S, Yi M   +9 more
doaj  

Improvement in both severe obsessive–compulsive disorder and refractory tardive dystonia following electroconvulsive therapy: A case report

PCN Reports, 2022
Background Obsessive–compulsive disorder (OCD) is often resistant to treatment and may be complicated by tardive dystonia (TDt) with the use of neuroleptics. Furthermore, patients with TDt often have an inadequate response to pharmacotherapy.
Yasuha Mihara, Koji Otsuki, Mai Hayashi, Satoko Yamashita, Michiharu Nagahama, Maiko Hayashida, Rei Wake, Sadayuki Hashioka, Satoshi Abe, Masatoshi Inagaki   +9 more
doaj   +1 more source

Teacher and student learning through a Teacher Design Team (TDT) [PDF]

, 2015
The change from teacher dominated to student controlled classrooms is not easy as teachers fear poorer learning. However, in context based education students need more autonomy.
Coenders, Fer
core   +1 more source

UbcH5a and UbcH6 promote TdT ubiquitylation.

, 2012
(A) UbcH5a enhances TdT ubiquitylation in 293 T cells. 293 T cells were transfected with plasmids encoding His-Ub (lanes 1, 3 to 5), Myc-TdT (lanes 2 to 5), and/or Flag-UbcH5a (lanes 1, 2, 4 and 5) in the indicated combinations.
Takuro Matsumoto (152830), Tomoyoshi Kato (152813), Sachiko Ando (152827), So Maezawa (152806), Kotaro Koiwai (152844), Osamu Koiwai (152848), Takahide Hayano (152836), Masahiro Suzuki (152839), Yoshihiro Nishiyama (152821), Rie Fukushima (152809), Toyofumi Matsushita (152811), Yoshiki Takagaki (152817), Kousuke Kouda (152833)   +12 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source