Results 151 to 160 of about 306,372 (291)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Detection of polyphenols-to-amino acids ratio in Wuyi Rock Tea <i>via</i> CARS-PLSR processing of near infrared spectroscopy. [PDF]

RSC Adv
Xu Z, Jiang X, Chen Q, Cai P.
europepmc   +1 more source

Impact of Nitrogen Fertilizer Applications on Surface Water Nitrate Levels within a Kenyan Tea Plantation [PDF]

, 2012
Justin K. Maghanga, John L. Kituyi, P. Kisinyo, W. K. Ng’etich   +3 more
openalex   +1 more source

Biomimetic Adaptive Hydrothermal Balance Fabric‐Based Dual‐Interface Solar Evaporator for Efficient and Stable Desalination

Advanced Science, EarlyView.
This study combines the biological structure of octopuses with the “3D structure” of spacer fabrics to fabricate a dual‐interface solar evaporator with adaptive hydrothermal balance. Water adaptation is achieved through the differentiated design of the upper and lower layers, and dynamic hydrothermal balance is realized by dynamically regulating the ...
Ning Niu, Lingjie Yu, Jiaguang Meng, Wei Fan, Kaili Chen, Wanwan He, Yongzhen Wang, Yaming Liu, Ying Li, Zhaoling Sun, Chao Zhi   +10 more
wiley   +1 more source

A Retrospective Long-Term Follow-Up of the Randomized Study: Total Endoscopic Ablation of Patients With Long-Standing Persistent Atrial Fibrillation. [PDF]

Interdiscip Cardiovasc Thorac Surg
Wickbom A, Fengsrud E, Ahlsson A.
europepmc   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine From Xylose in Escherichia Coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Multidimensional Profiling of Chinese Sweet Tea <i>(Lithocarpus litseifolius)</i>: Processing Methods Modulate Sensory Properties, Bioaccessibility and Prebiotic Potential via Gut Microbiota Regulation. [PDF]

Foods
Zeng Z, Zhang Q, Zhang L, Hu B, Wen X, Wang Z, Wu W, Liu Y.   +7 more
europepmc   +1 more source

Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling

Advanced Science, EarlyView.
This review summarizes green and low‐carbon strategies throughout the entire life cycle of polyester plastics, including sustainable monomer synthesis, optimization polymerization, efficient recycling, and advanced upcycling technologies. The synergistic implementation of these strategies is expected to significantly promote the development of a ...
Jinzhou Li, Junliang Chen, Yingbing Zhang, Li Wang, Pin Gao, Jianping Yang   +5 more
wiley   +1 more source

Molluscicidal Activity of <i>Camellia Sinensis</i> (Green Tea) and <i>Camellia sinensis</i> var. Assamica (Purple Tea) Extracts Against <i>Biomphalaria pfeifferi,</i> the Major Vector Snail of Human Schistosomiasis in Sub-Saharan Africa. [PDF]

J Parasitol Res
Samoo N, Nyangacha R, Mbugua A, Mwangi I, Syengo CK, Laidemitt M, Mutuku M.   +6 more
europepmc   +1 more source

Molecular Diode‐Based Covalent Organic Frameworks: Imine Orientation‐Driven Acid‐Base Switching Photocatalytic H2 Production

Advanced Science, EarlyView.
Molecular diode‐based covalent organic frameworks (COFs) enable pH‐responsive current rectification, dynamically reversing electron flow to toggle photocatalytic hydrogen evolution activity between acidic and alkaline environments. ABSTRACT Donor–acceptor type covalent organic frameworks (D–A COFs) have emerged as a promising class of photocatalytic ...
Tianyi Liu, Yunjie Lang, Ning Sun, Xu Fang, Jinhua Rao, Yuchun Xu, Zhen Li, Weiqiao Deng   +7 more
wiley   +1 more source