Results 71 to 80 of about 1,915,493 (292)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Patent Races with Dynamic Complementarity [PDF]

Recent models of multi-stage R&D have shown that a system of weak intellectual property rights may lead to faster innovation by inducing firms to share intermediate technological knowledge.
A. Blasco
core  

Regional specialised observatories networks in technological development and innovation exemplified by the Silesia Voivodship [PDF]

, 2013
The Regional Specialised Observatories Network is a systemic tool to encourage interdisciplinary cooperation between the key participants of the regional innovation system in order to build the competitive advantage of the region. The network responds
Bondaruk, Jan, Gieroszka, Agnieszka, Kruczek, Mariusz, Siwek – Skalny, Anna, Uszok, Elżbieta   +4 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The digital silver lining of the pandemic: The impact on preservice teachers' technological knowledge and beliefs. [PDF]

Educ Inf Technol (Dordr), 2023
Brianza E, Schmid M, Tondeur J, Petko D.
europepmc   +1 more source

Technological Progress under Learning by Imitation [PDF]

We analyse technological progress when knowledge has a large tacit component so that transmission of knowledge takes place through direct personal imitation.
Morgan Kelly
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Technological knowledge progress: Were famous laws almost correct in developing and emerging economies? [PDF]

PLoS One, 2023
Amavilah VH, Rodriguez Andres A.
europepmc   +1 more source

Knowledge Flows and Productivity [PDF]

National and international flows of knowledge are fundamental determinants of technological progress. In this article we review the existing literature on knowledge flows and we propose a method for estimating them, based on patent citations.
Giovanni Peri
core  

Technological effects and scientific knowledge [PDF]

, 2015
En este ensayo queremos examinar ciertos aspectos del papel ontológico y cognitivo que ejerce la tecnología en la ciencia. Nos interesa resaltar el hecho de que la tecnología es capaz de producir cierta clase de fenómenos donde no siempre es claro si los
Mejía Barreto, Lorena, Prieto Mendoza, Carlos, Zavala, Nydia Lara   +2 more
core