Results 51 to 60 of about 414,034 (311)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Perceptions of technology integration in algebra instruction among pre-service mathematics teachers: a case study in the Upper East region of Ghana

Cogent Education
The study examines pre-service mathematics teachers’ perceptions of the integration of technology into algebra education. With the growing emphasis on technology in education, it is crucial to understand how pre-education teachers see technology and ...
Stanley Appiah Essuman, Eric Magnus Wilmot   +1 more
doaj   +1 more source

Local Engineers as Knowledge Liaison

Annals of Business Administrative Science, 2013
Developing localized products that accurately reflect the needs of local customers became an important issue for many Japanese companies that have globally expanded using standardized products.
Heejin KIM
doaj   +1 more source

Sleep, Knowledge, Technology. An Introduction

, 2023
Historical Social Research, 48(2), 7 ...
Ahlheim, Hannah, Zifonun, Dariuš, Zillien, Nicole   +2 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Educational Methodical and Technological Knowledge in Library and Information Activities

Библиосфера
Digital and sociocultural transformations have influenced changes in the content of library activities and the expansion of its boundaries. The emergence of new methods and forms of working with information and library users, the development of new ...
I. S. Pilko
doaj   +1 more source

Integrating ICT in Teaching Accounting in Secondary Schools: A Systematic Literature Review [PDF]

Journal of Education and Learning Technology
This study explored the integration of Information and Communication Technology in teaching Accounting in secondary schools. Utilizing Mishra and Koehler’s (2006) Technological Pedagogical Content Knowledge (TPACK) and a systematic literature review to ...
Andiswa Pride Muanalo, Sithembele Goodman Ndovela   +1 more
doaj   +1 more source

Performance Analysis of a Wind Turbine Pitch Neurocontroller with Unsupervised Learning

Complexity, 2020
In this work, a neural controller for wind turbine pitch control is presented. The controller is based on a radial basis function (RBF) network with unsupervised learning algorithm.
J. Enrique Sierra-García, Matilde Santos   +1 more
doaj   +1 more source