Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Long-Run Growth and the Evolution of Technological Knowledge [PDF]
The long-run evolution of per-capita income exhibits a structural break often associated with the Industrial Revolution. We follow Mokyr (2002) and embed the idea that this structural break reflects a regime switch in the evolution of technological ...
Hendrik Hakenes, Andreas Irmen
core
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Why New Business Development Projects Fail: Coping with the Differences of Technological versus Market Knowledge [PDF]
Managing through projects has become important for generating new knowledge to cope with technological and market discontinuities. This paper examines how the fit between the creation of technological and market knowledge and important project management
Volberda, H.W. +2 more
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Science Teachers’ Knowledge of Technology, its Usage and Challenges Faced during Integration
Universal Journal of Educational ResearchThis study investigated the knowledge of science teachers in educational technologies and how they are integrated in teaching science vis-à-vis their pedagogical content knowledge.
Emmanuel Awundin Azumah +1 more
doaj +1 more source
The digital silver lining of the pandemic: The impact on preservice teachers' technological knowledge and beliefs. [PDF]
Educ Inf Technol (Dordr), 2023 Brianza E, Schmid M, Tondeur J, Petko D.
europepmc +1 more source
Developing TPACK: Envisioning Technological Pedagogical Reasoning
, 2016 In this chapter, we explore and propose that teachers undertake technological pedagogical reasoning, which can assist in deepening an understanding of how we can represent the knowledge base of teaching.
Sim, Cheryl +5 more
core +1 more source