Results 41 to 50 of about 414,034 (311)

Validity of the Science E-Module Based on the 7E Learning Cycle Model Integrated Technological Knowledge

open access: yesJurnal PAJAR (Pendidikan dan Pengajaran)
Prospective elementary school teacher students need to understand one of the subjects, namely science, which is taught through the Elementary Science Learning course. In learning, it was found that lecturers dominated lecture activities.
Dea Mustika   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

The Effects of Knowledge Versus Production Boundaries on Firm Survival through Systemic Technological Change [PDF]

open access: yes, 2013
Firms that develop complex products are at greater risk from systemic technological change, which alters the way product components work together, and can also affect the nature of demand for a product.
Woroniecki, Jean
core  

Assessing Teachers’ Technological, Pedagogical, and Content Knowledge

open access: yes, 2017
TPACK, originally conceived by Mishra and Koehler (2006), was developed as a framework to better understand the knowledge and competencies required for teachers to effectively integrate technology in the classroom (Koehler & Mishra, 2009; Koh, Chai ...
Walker, Reshid Xavier.
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

MODERN EUROPEAN EXPERIENCE OF PRACTICAL TEACHER TRAINING

open access: yesОсвітологічний дискурс, 2021
The article considers the issue of studying modern European experience of practical teacher training. It was found out that efficiency of preparing future teachers to their practical activity directly depends on all the levels – from top to bottom ...
Наталія Кошарна
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The integration of new technologies : the stakes of knowledge [PDF]

open access: yes, 2010
In order to remain competitive in an increasingly competitive international context, French companies are forced to follow one or more of various possible routes: relocating some of the activities, optimizing the design and / or production process, or ...
AOUSSAT, Améziane   +7 more
core   +1 more source

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