Results 81 to 90 of about 957 (147)

Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis

, 2016
Teixobactin represents the first member of a newly discovered class of antibiotics that act through inhibition of cell wall synthesis. Teixobactin binds multiple bactoprenol-coupled cell wall precursors, inhibiting both peptidoglycan and teichoic acid ...
Schneider, Tanja, Lewis, Kim, Conlon, Brian P., Engels, Ina, Götz, Friedrich, Nuxoll, Austin, Homma, Tomoyuki, Ebner, Patrick, Gandt, Autumn Brown   +8 more
core   +1 more source

The Necessity of d‑Thr in the New Antibiotic Teixobactin: A Molecular Dynamics Study

, 2019
Ever since the discovery of the new antibiotic teixobactin, studies of its structure–activity relationships have never ceased. Here we focus on the chirality of the threonine (Thr) residue, which belongs to the ring motif of teixobactin and plays an ...
Mu, Yuguang, Weifeng Li (286014), Mary B. Chan-Park, Weifeng Li, Chan-Park, Mary B., Liu, Yang, Yang Liu (4829), Mary B. Chan-Park (1277490), Yang Liu, Yuguang Mu, Li, Weifeng, Yuguang Mu (29465)   +11 more
core   +1 more source

Synthesis of Teixobactin Analogues and their Biological Evaluation

, 2019
The work herein is part of my PhD for four years (April 2015- October 2018) at Lincoln University, UK. I have had the opportunity to travel to Temple University, Philadelphia, the USA, to advance my techniques and work on other collaborated projects.
openaire   +2 more sources

Simplified teixobactin analogues to target superbugs

, 2018
Ishwar Singh speaks to Benjamin Walden, Commissioning Editor. Ishwar Singh is a Senior Lecturer in biological chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Senior Research Fellowship, DANIDA, Denmark and CSIR, India.
Ishwar Singh, Benjamin Walden
openaire   +1 more source

Linking molecular architecture to antibacterial functions: a chemical biology view of cyclic depsipeptides. [PDF]

Front Chem
Baravkar S, Thombare VJ, Wu Y, Patil NA.
europepmc   +1 more source

Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in <i>Enterococcus faecalis</i>. [PDF]

Antimicrob Agents Chemother
Darnell RL, Knottenbelt MK, Rose OE, Cleary CSB, Todd Rose FO, Hodgkinson H, Wu Y, Hussein M, Velkov T, Gebhard S, Cook GM.   +10 more
europepmc   +1 more source

The Role of Greasy Residues in Teixobactin Derivatives [PDF]

Biophysical Journal, 2019
Po-Chao Wen, Emad Tajkhorshid, Susan B. Rempe   +2 more
openaire   +1 more source

Mining Microbial Dark Matter: Advanced Cultivation Techniques for Bioactive Compound Discovery. [PDF]

Pharmaceuticals (Basel)
Ji M, Ma B, Dong J, Liu S, Shi Y, Bu M, Wang L, Liu L.   +7 more
europepmc   +1 more source

Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29. [PDF]

J Org Chem, 2023
Krumberger M, Li X, Kreutzer AG, Peoples AJ, Nitti AG, Cunningham VA, Jones CR, Achorn C, Ling LL, Hughes DE, Nowick JS.   +10 more
europepmc   +1 more source

Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation. [PDF]

J Med Chem
Malkawi E, Parmar A, Das S, Newire E, Jones CM, Morrison KA, Karak M, Blanc F, Harper N, Lakshminarayanan R, Poh ZS, Verma NK, Unsworth J, Hughes DE, Ling LL, Cochrane SA, Hope W, Singh I.   +17 more
europepmc   +1 more source