Results 71 to 80 of about 957 (147)
Simplified Teixobactin Analogues to Target Superbugs [PDF]
Future Medicinal Chemistry, 2017 Ishwar Singh speaks to Benjamin Walden, Commissioning Editor. Ishwar Singh is Senior Lecturer in biological chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Senior Research Fellowship, DANIDA, Denmark and CSIR, India.
openaire +1 more source
Investigating resistance in Enterococcus faecalis against the new antibiotic teixobactin
, 2018 The rapid rise and spread of multi-drug resistant (MDR) pathogens has become a daunting reality for many countries world-wide driving the need for new antimicrobials with novel targets.
Knottenbelt, Melanie Kym
core +1 more source
Mechanism of action of pseudopteroxazole and pseudopterosin G: Diterpenes from marine origin
PROTEOMICS, Volume 24, Issue 10, May 2024.Abstract Pseudopteroxazole (Ptx) and the pseudopterosins are marine natural products with promising antibacterial potential. While Ptx has attracted interest for its antimycobacterial activity, pseudopterosins are active against several clinically relevant pathogens. Both compound classes exhibit low cytotoxicity and accessibility to targeted synthesis,
Niklas B. M. Janzing +6 more
wiley +1 more source
What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley +1 more source
Super‐resolution fluorescence microscopy for investigating bacterial cell biology
Molecular Microbiology, Volume 121, Issue 4, Page 646-658, April 2024.Current developments in super‐resolution fluorescence microscopy are opening up new possibilities in molecular and cellular bacteriology. The latest applications are presented including the use of MINFLUX nanoscopy for research into secretion systems.
Alexander Carsten +2 more
wiley +1 more source
Design and Development of Isobactins: Prodrugs of Teixobactin and Teixobactin Derivatives [PDF]
In my thesis I aim to develop novel antibiotics in the fight against Gram-positive bacteria. In Chapter 1, I summarize the outlook of antibiotic resistance and how a new antibiotic, teixobactin, serves as a promising antibiotic candidate for drug ...
Jones, Chelsea Rae
core
Investigating Teixobactin Tolerance in Enterococcus faecalis
, 2018 The rapid rise of antimicrobial resistance (AMR) poses a global threat to human health. Key to combating antimicrobial resistance will be to increase our understanding of how resistance develops. Conventional antimicrobial susceptibility assays determine
Todd Rose, Francesca Olivia
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OBSTRUCTION IN THE DISCOVERY OF NEW ANTIBIOTIC DRUGS:
Journal of University Medical & Dental College, 2017 : After discovery of antibiotic in 1928, there are 100 of compounds, but after 1987 no new class had been discovered. Infectious diseases are third leading cause of deaths in US and second leading cause in whole world. Obstruction in the discovery of new
Farjad Afzal, Asma Afzal, Sidra Manzoor
doaj
Teixobactin: A Paving Stone toward a New Class of Antibiotics?
, 2020 Antimicrobial resistance is a serious threat to human health worldwide, prompting research efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy.
Chopra, Sidharth +3 more
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Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II
, 2019 The prevalence of life-threatening, drug resistant microbial infections has challenged researchers to consider alternatives to currently available antibiotics. Teixobactin is a recently discovered “resistance proof” antimicrobial peptide that targets the
Kotsogianni, Ioli +32 more
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