Results 61 to 70 of about 957 (147)

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, Volume 44, Issue 5, Page 715-756, September/October 2025.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Carrier Protein Interaction with Competing Adenylation and Epimerization Domains in a Nonribosomal Peptide Synthetase Analyzed by FRET

Angewandte Chemie, Volume 136, Issue 20, May 13, 2024.
In nonribosomal peptide synthetases, the peptidyl‐carrier‐protein (PCP) of each module tethers the amino acid to be incorporated into the peptide product. Its interaction with multiple catalytic domains is barely studied. We reveal a surprising competition of the adenylation (A) and epimerization (E) domains for the PCP in an A‐PCP‐E module.
Anna‐Lena Feldberg, Florian Mayerthaler, Jennifer Rüschenbaum, Jonas Kröger, Henning D. Mootz   +4 more
wiley   +2 more sources

ssNMR raw data 'Teixobactin kills bacteria by a two-pronged attack on the cell envelope'

, 2022
ssNMR to 'Teixobactin kills bacteria by a two-pronged attack on the cell envelope' Experiments 1 - 5 acquired in DOPC liposomes with 13C,15N-teixobactin and 12C,14N-Lipid II. Experiments 20-23 acquired in DOPC liposomes with 13C,15N-teixobactin and 13C,
Rhythm Shukla, Markus Weingarth
core   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Structural studies suggest aggregation as one of the modes of action for teixobactin [PDF]

Chemical Science, 2018
Combination of solution and solid state NMR yields a molecular level view of the interactions between antibiotic teixobactin and bacterial cell wall building block lipid II.
Carl Öster, Grzegorz P. Walkowiak, Dallas E. Hughes, Amy L. Spoering, Aaron J. Peoples, Anita C. Catherwood, Julie A. Tod, Adrian J. Lloyd, Torsten Herrmann, Kim Lewis, Christopher G. Dowson, Józef R. Lewandowski   +11 more
openaire   +3 more sources

Elucidating the Mechanism of Action of Teixobactin [PDF]

, 2019
This dissertation work is centered on understanding the structure and mechanism of action of the peptide antibiotic, teixobactin. Each chapter shares the themes of understanding the molecular recognition and supramolecular assembly of teixobactin.
Yang, Hyunjun
core  

Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin

, 2019
This paper describes the chemical synthesis, X-ray crystallographic structure, and antibiotic activity assay of lactam analogues of teixobactin and explores ring-expanded analogues of teixobactin with β3-homo amino acids.
Hyunjun Yang (2813545), Xingyue Li (5168501), James S. Nowick (1272555), Arthur V. Pishenko (8103014)   +3 more
core   +2 more sources

The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment

Chemistry – A European Journal, Volume 30, Issue 38, July 5, 2024.
This review covers the most recent advances in the development of inhibitors for the bacterial enzyme sortase A (SrtA), where it is considered as a major target for antivirulence therapy. Sortases are key enzymes regulating bacterial adherence to host cells and are considered major virulence factors.
Jordi C. J. Hintzen, Helal Abujubara, Daniel Tietze, Alesia A. Tietze   +3 more
wiley   +1 more source