Results 41 to 50 of about 734 (134)

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

Beilstein Journal of Organic Chemistry, 2016
Rising resistance to current clinical antibacterial agents is an imminent threat to global public health and highlights the demand for new lead compounds for drug discovery.
Darcy J. Atkinson, Briar J. Naysmith, Daniel P. Furkert, Margaret A. Brimble   +3 more
doaj   +1 more source

Teixobactin: A New Class of Antibiotic [PDF]

SOJ Microbiology & Infectious Diseases, 2015
Over-use of antibiotics (although, arguably, acquired resistance is eventually inevitable). Over-use has occurred through medics handing antibiotics for no good reason (a common case here is for people who have viral infections like the common cold or influenza being mis-prescribed).The so-termed “age of the superbug”, although genetically inevitable ...
openaire   +1 more source

Structure-Activity Relationship of Arg10-Teixobactin: A Recently Discovered Antimicrobial Peptide

Proceedings, 2017
The emergence of multidrug resistant bacteria has a direct impact on global public health due to the reduced potency of existing antibiotics against pathogens [1]. [...]
Fernando Albericio, Shimaa A. H. Abdel Monaim, Yahya E. Jad, Gerardo A. H. Acosta, Estelle J. Ramchuran, Ayman El-Faham, Thavendran Govender, Hendrik G. Kruger, Beatriz G. de la Torre   +8 more
doaj   +1 more source

TEIXOBACTIN - A GAME CHANGER ANTIBIOTIC

Era's Journal of Medical Research, 2020
Ateam of scientist under the supervision of Kim Lewis from Northeastern University has discovered a novel antibiotic called Teixobactin, which kills the bacteria by inhibiting them from building their outer protein envelop. The bacterial resistance interference are key challenges to the global health.
Sahil Hussain, Neelam Yadav
openaire   +1 more source

Alanine scan reveals modifiable residues in teixobactin [PDF]

Chemical Communications, 2017
An alanine scan reveals the tolerance of amino acids in teixobactin toward substitution.
K. H. Chen, S. P. Le, X. Han, J. M. Frias, J. S. Nowick   +4 more
openaire   +4 more sources

Application of iChip to Grow “Uncultivable” Microorganisms and its Impact on Antibiotic Discovery

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Antibiotics have revolutionized modern medicine, allowing significant progress in healthcare and improvement in life expectancy. Development of antibiotic resistance by pathogenic bacteria is a natural phenomenon; however, the rate of antibiotic ...
Rinzhin T. Sherpa, Caretta J. Reese, Hamidreza Montazeri Aliabadi   +2 more
doaj   +1 more source

Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, Volume 44, Issue 5, Page 715-756, September/October 2025.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Carrier Protein Interaction with Competing Adenylation and Epimerization Domains in a Nonribosomal Peptide Synthetase Analyzed by FRET

Angewandte Chemie, Volume 136, Issue 20, May 13, 2024.
In nonribosomal peptide synthetases, the peptidyl‐carrier‐protein (PCP) of each module tethers the amino acid to be incorporated into the peptide product. Its interaction with multiple catalytic domains is barely studied. We reveal a surprising competition of the adenylation (A) and epimerization (E) domains for the PCP in an A‐PCP‐E module.
Anna‐Lena Feldberg, Florian Mayerthaler, Jennifer Rüschenbaum, Jonas Kröger, Henning D. Mootz   +4 more
wiley   +2 more sources