Results 41 to 50 of about 957 (147)

The antibiotic resistance crisis and the development of new antibiotics. [PDF]

Microb Biotechnol
The current Lilliput review analyses the question whether scientific or economic hurdles prevented the registration of new antibiotics. Scientifically, substantial progress has been achieved over recent years. The lack of profitability for costly novel antibiotic development necessitates push and pull efforts of the public sector to complement what the
Brüssow H.
europepmc   +2 more sources

Structural and Functional Mimicry of the Antimicrobial Defensin Plectasin by Analogues with Engineered Backbone Composition. [PDF]

Chembiochem
Backbone engineering in the disulfide‐rich miniprotein plectasin, a Lipid‐II binding antimicrobial defensin, leads to proteomimetic analogues that reproduce the fold and function of the natural product on scaffolds with improved stability to degradation by protease enzymes.
Harmon TW, Song J, Gulewicz AJ, Di YP, Horne WS.   +4 more
europepmc   +2 more sources

Supramolecular Interactions of Teixobactin Analogues in the Crystal State. [PDF]

J Org Chem, 2023
ABSTRACT Teixobactin is a potent peptide antibiotic against Gram-positive bacteria that binds to lipid II and related peptidoglycan precursors and disrupts the cell membrane. This paper presents the X-ray crystallographic structure of the N -methylated teixobactin analogue
Yang H, Kreutzer AG, Nowick JS.
europepmc   +5 more sources

In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates

Frontiers in Microbiology, 2018
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) are included on the WHO high priority list of pathogens that require urgent intervention.
Estelle J. Ramchuran, Anou M. Somboro, Shimaa A. H. Abdel Monaim, Daniel G. Amoako, Raveen Parboosing, Hezekiel M. Kumalo, Nikhil Agrawal, Fernando Albericio, Fernando Albericio, Beatriz G. de La Torre, Linda A. Bester   +10 more
doaj   +1 more source

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

Biotechnology Reports, 2022
The microorganisms that have developed resistance to available therapeutic agents are threatening the globe and multidrug resistance among the bacterial pathogens is becoming a major concern of public health worldwide.
Ragi Jadimurthy, Shilpa Borehalli Mayegowda, S.Chandra Nayak, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal S. Rangappa   +4 more
doaj   +1 more source

A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

mBio, 2022
With the overmining of actinomycetes for compounds acting against Gram-negative pathogens, recent efforts to discover novel antibiotics have been focused on other groups of bacteria.
Negar Shahsavari, Boyuan Wang, Yu Imai, Miho Mori, Sangkeun Son, Libang Liang, Nils Böhringer, Sylvie Manuse, Michael F. Gates, Madeleine Morrissette, Rachel Corsetti, Josh L. Espinoza, Chris L. Dupont, Michael T. Laub, Kim Lewis   +14 more
doaj   +1 more source

Single Atom Engineered Antibiotics Overcome Bacterial Resistance. [PDF]

Adv Mater
Single atoms of manganese, tightly bonded to nitrogen‐doped carboxylated graphene, exhibit potent antibacterial properties and bypass bacterial resistance development, even after thirty bacterial generations. Antibacterial activity is observed against both Gram‐negative and Gram‐positive bacteria, as well as in in‐vivo models, while the material is ...
Panáček D, Belza J, Hochvaldová L, Baďura Z, Zoppellaro G, Šrejber M, Malina T, Šedajová V, Paloncýová M, Langer R, Zdražil L, Zeng J, Li L, Zhao E, Chen Z, Xiong Z, Li R, Panáček A, Večeřová R, Kučová P, Kolář M, Otyepka M, Bakandritsos A, Zbořil R.   +23 more
europepmc   +2 more sources

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

Nature Communications, 2019
The presence of the unnatural amino acid l-allo-enduracidine in the cyclic scaffold of teixobactin complicates its total synthesis. Here, the authors developed a convergent strategy for the scalable synthesis teixobactin and found two potent analogous.
Yu Zong, Fang Fang, Kirsten J. Meyer, Liguo Wang, Zhihao Ni, Hongying Gao, Kim Lewis, Jingren Zhang, Yu Rao   +8 more
doaj   +1 more source

Teixobactin: A New Class of Antibiotic [PDF]

SOJ Microbiology & Infectious Diseases, 2015
Over-use of antibiotics (although, arguably, acquired resistance is eventually inevitable). Over-use has occurred through medics handing antibiotics for no good reason (a common case here is for people who have viral infections like the common cold or influenza being mis-prescribed).The so-termed “age of the superbug”, although genetically inevitable ...
openaire   +1 more source

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini, Linda M. Haugaard‐Kedström, Craig A. Hutton, John A. Karas   +3 more
wiley   +2 more sources