Results 21 to 30 of about 734 (134)

A Fluorescent Teixobactin Analogue [PDF]

ACS Chemical Biology, 2020
This report describes the first synthesis and application of a fluorescent teixobactin analogue that exhibits antibiotic activity and binds to the cell walls of Gram-positive bacteria. The teixobactin analogue, Lys(Rhod)9,Arg10-teixobactin, has a fluorescent tag at position 9 and an arginine in place of the natural allo-enduracididine residue at ...
Michael A. Morris, Melody Malek, Mohammad H. Hashemian, Betty T. Nguyen, Sylvie Manuse, Kim Lewis, James S. Nowick   +6 more
openaire   +4 more sources

Elucidation of the Teixobactin Pharmacophore [PDF]

ACS Chemical Biology, 2016
This paper elucidates the teixobactin pharmacophore by comparing the arginine analogue of teixobactin Arg10-teixobactin to seven homologues with varying structure and stereochemistry. The roles of the guanidinium group at position 10, the stereochemistry of the macrolactone ring, and the "tail" comprising residues 1-5 are investigated.
Yang, Hyunjun, Chen, Kevin, Nowick, James   +2 more
openaire   +4 more sources

The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study

mSystems, 2020
Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from a hitherto ...
Maytham Hussein, John A. Karas, Elena K. Schneider-Futschik, Fan Chen, James Swarbrick, Olivia K. A. Paulin, Daniel Hoyer, Mark Baker, Yan Zhu, Jian Li, Tony Velkov   +10 more
doaj   +1 more source

Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model

Pathogens, 2020
The use of antibiotics is a vital means of treating infections caused by the bacteria Bacillus (B.) anthracis. Importantly, with the potential future use of multidrug-resistant strains of B.
William S. Lawrence, Jennifer E. Peel, Satheesh K. Sivasubramani, Wallace B. Baze, Elbert B. Whorton, David W. C. Beasley, Jason E. Comer, Dallas E. Hughes, Losee L. Ling, Johnny W. Peterson   +9 more
doaj   +1 more source

Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance

mSphere, 2019
Teixobactin is a new antimicrobial of significant interest. It is active against a number of multidrug-resistant pathogens, including Staphylococcus aureus and Enterococcus faecalis, with no reported mechanisms of teixobactin resistance.
Rachel L. Darnell, Melanie K. Knottenbelt, Francesca O. Todd Rose, Ian R. Monk, Timothy P. Stinear, Gregory M. Cook   +5 more
doaj   +1 more source

The antibiotic resistance crisis and the development of new antibiotics. [PDF]

Microb Biotechnol
The current Lilliput review analyses the question whether scientific or economic hurdles prevented the registration of new antibiotics. Scientifically, substantial progress has been achieved over recent years. The lack of profitability for costly novel antibiotic development necessitates push and pull efforts of the public sector to complement what the
Brüssow H.
europepmc   +2 more sources

Structural and Functional Mimicry of the Antimicrobial Defensin Plectasin by Analogues with Engineered Backbone Composition. [PDF]

Chembiochem
Backbone engineering in the disulfide‐rich miniprotein plectasin, a Lipid‐II binding antimicrobial defensin, leads to proteomimetic analogues that reproduce the fold and function of the natural product on scaffolds with improved stability to degradation by protease enzymes.
Harmon TW, Song J, Gulewicz AJ, Di YP, Horne WS.   +4 more
europepmc   +2 more sources

X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore [PDF]

Chemical Communications, 2017
X-ray crystallography reveals key interactions in the pharmacophore of the antibiotic teixobactin.
H. Yang, D. R. Du Bois, J. W. Ziller, J. S. Nowick   +3 more
openaire   +4 more sources

Synthesis and application of fluorescent teixobactin analogs

, 2022
Teixobactin is a promising new antibiotic that kills a spectrum of Gram-positive pathogens that are considered to be urgent threats by the CDC and the WHO. Better understanding of the novel mechanism of action of teixobactin may assist in developing new antibiotics and furthering our understanding of antibiotic resistance.
Morris, Michael A, Jones, Chelsea R, Nowick, James S   +2 more
openaire   +4 more sources

Synthesis and structure−activity relationships of teixobactin [PDF]

Annals of the New York Academy of Sciences, 2019
AbstractThe discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial ...
Karas, JA, Chen, F, Schneider-Futschik, EK, Kang, Z, Hussein, M, Swarbrick, J, Hoyer, D, Giltrap, AM, Payne, RJ, Li, J, Velkov, T   +10 more
openaire   +3 more sources