Results 21 to 30 of about 957 (147)

Synthesis and structure−activity relationships of teixobactin [PDF]

Annals of the New York Academy of Sciences, 2019
AbstractThe discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial ...
Karas, JA, Chen, F, Schneider-Futschik, EK, Kang, Z, Hussein, M, Swarbrick, J, Hoyer, D, Giltrap, AM, Payne, RJ, Li, J, Velkov, T   +10 more
openaire   +5 more sources

Mode of action of teixobactins in cellular membranes [PDF]

Nature Communications, 2020
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind ...
Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth   +14 more
doaj   +7 more sources

Alanine scan reveals modifiable residues in teixobactin [PDF]

Chemical Communications, 2017
An alanine scan reveals the tolerance of amino acids in teixobactin toward substitution.
K. H. Chen, S. P. Le, X. Han, J. M. Frias, J. S. Nowick   +4 more
openaire   +6 more sources

Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery [PDF]

ACS Infectious Diseases, 2017
Increasing bacterial resistance against current antibiotics and lack of new molecules to combat bacterial resistance are key challenges to global health. There is, therefore, a continuing need to develop new antibiotics. Teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as ...
William D. Fiers, Mark Craighead, Ishwar Singh   +2 more
core   +5 more sources

Synthesis and Biological Evaluation of a Teixobactin Analogue

Organic Letters, 2015
The first synthesis and biological activity of a teixobactin analogue is reported. Substitution of the unusual L-allo-enduracididine residue by the naturally occurring L-arginine was achieved, and the analogue gave an activity trend similar to that of teixobactin (against Gram-postive bacteria) and meropenem, which was approved by the FDA in 1996.
Yahya E, Jad, Gerardo A, Acosta, Tricia, Naicker, Melissa, Ramtahal, Ayman, El-Faham, Thavendran, Govender, Hendrik G, Kruger, Beatriz G, de la Torre, Fernando, Albericio   +8 more
openaire   +3 more sources

SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP OF TEIXOBACTIN ANALOGUES [PDF]

Multi-drug resistant bacteria that are primarily unresponsive towards the available marketed antibiotics presents a threat to global health, leading to an increase in mortality and morbidity rate. Today, more than 700,000 people die annually as a consequence to the bacterial infections. This number is expected to rise to 10 million by 2050.
Malkawi, Ruba
openaire   +2 more sources

Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin

Journal of Medicinal Chemistry, 2018
Teixobactin, targeting lipid II, represents a new class of antibiotics with novel structures and has excellent activity against Gram-positive pathogens. We developed a new convergent method to synthesize a series of teixobactin analogues and explored structure-activity relationships.
Yu Zong, Xiuyun Sun, Hongying Gao, Kirsten J. Meyer, Kim Lewis, Yu Rao   +5 more
openaire   +3 more sources

Teixobactin, the first of a new class of antibiotics discovered by iChip technology? [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Teixobactin is a recently described antibiotic of a new class produced by a hitherto undescribed soil microorganism (provisionally named Eleftheria terrae). It was isolated with a new tool, the iChip, that allowed the environmental bacterium to grow and for the antibiotic it produced to be isolated and subsequently identified.
Piddock, Laura J V
openaire   +5 more sources

Vancomycin-Teixobactin Conjugates. [PDF]

J Am Chem Soc
Vancomycin continues to be a widely used antibiotic of last resort in treating drug-resistant pathogens despite the emergence of vancomycin-resistant strains such as vancomycin-resistant Enterococci (VRE). This communication reports that conjugation of vancomycin to a second antibiotic that targets a different region of lipid II enhances and rescues ...
Padilla MSTL, Nowick JS.
europepmc   +5 more sources

Antibiotic Resistance in the Elderly: Mechanisms, Risk Factors, and Solutions [PDF]

Microorganisms
Antibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs.
Nikolaos Theodorakis, Georgios Feretzakis, Christos Hitas, Magdalini Kreouzi, Sofia Kalantzi, Aikaterini Spyridaki, Iris Zoe Boufeas, Aikaterini Sakagianni, Evgenia Paxinou, Vassilios S. Verykios, Maria Nikolaou   +10 more
doaj   +2 more sources