Results 11 to 20 of about 734 (134)
New Teixobactin Analogues with a Total Lactam Ring [PDF]
ACS Medicinal Chemistry Letters, 2023 Teixobactin is a new antibiotic peptide with strong efficacy against several Gram-positive resistant bacteria, the structure of which is extremely difficult to obtain in the laboratory via multistep conventional synthesis. To face the increasing antibiotic resistant bacteria, it is fundamental to introduce new types of antibiotics with innovative ...
Wojciech Kamysz +2 more
exaly +4 more sources
Total synthesis of teixobactin [PDF]
Nature Communications, 2016 Teixobactin is a recently identified antibiotic that shows activity against drug resistant strains of bacteria. Here, the authors report a highly convergent total synthesis of this natural product, with sufficient flexibility to also allow the synthesis ...
Kang Jin +7 more
doaj +11 more sources
Investigation of Isobactin Analogues of Teixobactin [PDF]
ACS Medicinal Chemistry LettersAlthough teixobactin is a promising antibiotic drug candidate against Gram-positive bacteria, it aggregates to form gels that may limit intravenous administration. We previously reported O-acyl isopeptide prodrugs of teixobactin analogues that address the problem of gel formation while retaining antibiotic activity. We termed these compounds isobactins.
James Nowick +2 more
exaly +6 more sources
Mode of action of teixobactins in cellular membranes [PDF]
Nature Communications, 2020 The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind ...
Rhythm Shukla +14 more
doaj +7 more sources
Vancomycin-Teixobactin Conjugates. [PDF]
J Am Chem SocVancomycin continues to be a widely used antibiotic of last resort in treating drug-resistant pathogens despite the emergence of vancomycin-resistant strains such as vancomycin-resistant Enterococci (VRE). This communication reports that conjugation of vancomycin to a second antibiotic that targets a different region of lipid II enhances and rescues ...
Padilla MSTL, Nowick JS.
europepmc +5 more sources
Antibiotic Resistance in the Elderly: Mechanisms, Risk Factors, and Solutions [PDF]
MicroorganismsAntibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs.
Nikolaos Theodorakis +10 more
doaj +2 more sources
Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives. [PDF]
Chem Sci, 2022 O-Acyl isopeptide prodrug analogues of the antibiotic teixobactin are stable and non-gelating at acidic pH but convert to the corresponding active teixobactin analogues at neutral pH, thus overcoming limitations in intravenous dosing of teixobactin.
Jones CR +3 more
europepmc +5 more sources
Hijacking the Electron Train: Menaquinone-Binding Antimicrobial Peptides. [PDF]
ChembiochemMenaquinone is an emerging target for antimicrobial peptides. Could it be the new Achilles’ Heel of bacteria? The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority.
Matheson EJ, Cochrane SA.
europepmc +2 more sources
Teixobactin kills bacteria by a two-pronged attack on the cell envelope [PDF]
Nature, 2022 Adela Melcrová +2 more
exaly +2 more sources
Correction: Synergistic potential of Leu10-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus [PDF]
BMC MicrobiologyAugustine Jing Jie Koh +5 more
doaj +2 more sources