Investigation of the N-Terminus Amino Function of Arg10-Teixobactin [PDF]
Molecules, 2017 Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis.
Shimaa A H Abdel Monaim +2 more
exaly +6 more sources
Pharmaceutics, 2018 Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance.
Ruba Malkawi +2 more
exaly +5 more sources
Design and Development of Teixobactin Analog-Loaded Magnetic Nanocomposites for Biofilm Destruction and Pathogen Elimination [PDF]
Journal of Functional BiomaterialsAlthough teixobactin, a promising cyclic undecadepsipeptide, exhibits efficacy against Gram-positive bacteria due to its novel mode of action and low potential for resistance, its clinical application is limited by two key shortcomings: ineffectiveness ...
Huaxiang Lei +5 more
doaj +2 more sources
Synergistic potential of Leu10-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus [PDF]
BMC MicrobiologyStaphylococcus aureus (S. aureus) is a significant Gram-positive opportunistic pathogen behind many debilitating infections. β-lactam antibiotics are conventionally prescribed for treating S. aureus infections. However, the adaptability of S.
Augustine Jing Jie Koh +5 more
doaj +2 more sources
Drug repurposing of natural depsipeptide from Eleftheria terrae isolated via iChip for anti-breast cancer therapy [PDF]
Frontiers in PharmacologyGraphical AbstractDiagram showing a drug development process using AI. Left panel depicts molecular structures of teixobactin and clovibactin. Middle section illustrates pharmacochemistry, ADMET pharmacokinetics, and pharmacodynamics targeting with ...
Nuriyatul Fhatonah +9 more
doaj +2 more sources
MSystems, 2020 Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from a hitherto ...
Maytham Hussein +2 more
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Antimicrobial Effects of L-Chg10-Teixobactin against Enterococcus faecalis In Vitro [PDF]
Microorganisms, 2022 Objective: Teixobactin and its analogues are a new class of antibiotics that have no detectable bacterial resistance. This study was designed to determine the antibacterial and antibiofilm activities of a novel teixobactin analogue, L-Chg10-teixobactin ...
Alaa Jarkhi +6 more
doaj +2 more sources
Metabolic profiling unveils enhanced antibacterial synergy of polymyxin B and teixobactin against multi-drug resistant Acinetobacter baumannii [PDF]
Scientific ReportsThis untargeted metabolomics study investigated the synergistic antibacterial activity of polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis.
Maytham Hussein +13 more
doaj +2 more sources
Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs
Frontiers in Chemistry, 2020 Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA ...
VÍCTOR V Yim +2 more
exaly +3 more sources
Current Research in Structural Biology, 2020 The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be less ...
Kemin Tan +2 more
exaly +3 more sources