Results 31 to 40 of about 734 (134)
Computational Design of New Teixobactin Analogues as Inhibitors of Lipid II Flippase MurJ
Medical Sciences Forum, 2022 The peptidoglycan (PG) cell wall is an essential component of the bacterial cell structure, and crippling its synthesis is one of the most successful strategies in the continuing war against pathogenic bacteria.
Andreea Calianu, Radu Tamaian
doaj +1 more source
In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates
Frontiers in Microbiology, 2018 Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) are included on the WHO high priority list of pathogens that require urgent intervention.
Estelle J. Ramchuran +10 more
doaj +1 more source
Supramolecular Interactions of Teixobactin Analogues in the Crystal State. [PDF]
J Org Chem, 2023 ABSTRACT Teixobactin is a potent peptide antibiotic against Gram-positive bacteria that binds to lipid II and related peptidoglycan precursors and disrupts the cell membrane. This paper presents the X-ray crystallographic structure of the N -methylated teixobactin analogue
Yang H, Kreutzer AG, Nowick JS.
europepmc +5 more sources
Single Atom Engineered Antibiotics Overcome Bacterial Resistance. [PDF]
Adv MaterSingle atoms of manganese, tightly bonded to nitrogen‐doped carboxylated graphene, exhibit potent antibacterial properties and bypass bacterial resistance development, even after thirty bacterial generations. Antibacterial activity is observed against both Gram‐negative and Gram‐positive bacteria, as well as in in‐vivo models, while the material is ...
Panáček D +23 more
europepmc +2 more sources
Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds
Biotechnology Reports, 2022 The microorganisms that have developed resistance to available therapeutic agents are threatening the globe and multidrug resistance among the bacterial pathogens is becoming a major concern of public health worldwide.
Ragi Jadimurthy +4 more
doaj +1 more source
Nature Communications, 2019 The presence of the unnatural amino acid l-allo-enduracidine in the cyclic scaffold of teixobactin complicates its total synthesis. Here, the authors developed a convergent strategy for the scalable synthesis teixobactin and found two potent analogous.
Yu Zong +8 more
doaj +1 more source
A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP
mBio, 2022 With the overmining of actinomycetes for compounds acting against Gram-negative pathogens, recent efforts to discover novel antibiotics have been focused on other groups of bacteria.
Negar Shahsavari +14 more
doaj +1 more source
Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis
Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini +3 more
wiley +2 more sources
Teixobactin: a novel anti-infective agent [PDF]
Expert Review of Anti-infective Therapy, 2018 In 2015, a screen of bacterial strains produced a novel antibiotic with broad antimicrobial activity known as teixobactin [1].
openaire +2 more sources
Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok +11 more
wiley +2 more sources