Results 31 to 40 of about 957 (147)
Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM [PDF]
ACS Omega, 2021 The antibiotic teixobactin targets bacterial cell walls. Previous research has proposed that the active form of teixobactin is a nano-/micron-sized supramolecular assembly.
Paul Joshua Hurst +4 more
doaj +3 more sources
Total synthesis of teixobactin and its stereoisomers
Organic Chemistry Frontiers, 2018 The total syntheses of teixobactin and a series of its stereoisomers at positions 2, 5, 6, 10 and 11 were achieved via a combined strategy of solution and solid phase peptide synthesis.
L. Liu +6 more
openaire +2 more sources
Hijacking the Electron Train: Menaquinone-Binding Antimicrobial Peptides. [PDF]
ChembiochemMenaquinone is an emerging target for antimicrobial peptides. Could it be the new Achilles’ Heel of bacteria? The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority.
Matheson EJ, Cochrane SA.
europepmc +2 more sources
Correction: Synergistic potential of Leu10-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus [PDF]
BMC MicrobiologyAugustine Jing Jie Koh +5 more
doaj +2 more sources
A NEW NATURAL ANTIBIOTIC: TEIXOBACTIN
, 2016 Antibioticresistance is spreading faster than the introduction of new antimicrobials intoclinical practice, causing a public health crisis. Most antibiotics wereproduced by screening soil microorganisms. This limited resource of cultivablebacteria was overmined by the 1960s.
Aktas, Gulseren
openaire +2 more sources
Teixobactin: A Novel Antibiotic in Treatment of Gram Positive Bacterial Infections [PDF]
Journal of Clinical and Diagnostic Research, 2015 Sir, Antimicrobial resistance have emerged as a serious concern worldwide. In spite of the best effort in developing novel antimicrobial agents employing advanced techniques like computer-aided drug design, proteomics, genomics, combinatorial synthesis and high- throughput screening, there is lack of newer antibiotics in the process of development ...
Arunava Kali
doaj +3 more sources
mSystems, 2020 Antibiotics have served humankind through their use in modern medicine as effective treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly discovered natural antibiotics that was recently identified from a hitherto ...
Maytham Hussein +10 more
doaj +1 more source
Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus subtilis. [PDF]
Chem Sci, 2022 Teixobactin has been the source of intensive study and interest as a promising antibiotic, because of its excellent activity against drug-resistant Gram-positive pathogens and its novel but not yet fully understood mechanism of action that precludes drug
Morris MA +10 more
europepmc +2 more sources
mSphere, 2019 Teixobactin is a new antimicrobial of significant interest. It is active against a number of multidrug-resistant pathogens, including Staphylococcus aureus and Enterococcus faecalis, with no reported mechanisms of teixobactin resistance.
Rachel L. Darnell +5 more
doaj +1 more source
Computational Design of New Teixobactin Analogues as Inhibitors of Lipid II Flippase MurJ
Medical Sciences Forum, 2022 The peptidoglycan (PG) cell wall is an essential component of the bacterial cell structure, and crippling its synthesis is one of the most successful strategies in the continuing war against pathogenic bacteria.
Andreea Calianu, Radu Tamaian
doaj +1 more source