Results 51 to 60 of about 734 (134)
Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery [PDF]
ACS Infectious Diseases, 2017 Increasing bacterial resistance against current antibiotics and lack of new molecules to combat bacterial resistance are key challenges to global health. There is, therefore, a continuing need to develop new antibiotics. Teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as ...
William D. Fiers +2 more
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Understanding the Role of Macrocycle Size and Amide Linkage in Teixobactin Analogues
BiomoleculesTeixobactin is a promising antibiotic that targets cell wall biosynthesis in Gram-positive bacteria and displays a low propensity for resistance; however, its structural complexity presents challenges for analogue development and optimisation.
Ruba Malkawi +9 more
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Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen
Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth +3 more
wiley +1 more source
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth +3 more
wiley +1 more source
Chemistry – A European Journal, Volume 30, Issue 38, July 5, 2024.This review covers the most recent advances in the development of inhibitors for the bacterial enzyme sortase A (SrtA), where it is considered as a major target for antivirulence therapy. Sortases are key enzymes regulating bacterial adherence to host cells and are considered major virulence factors.
Jordi C. J. Hintzen +3 more
wiley +1 more source
Mechanism of action of pseudopteroxazole and pseudopterosin G: Diterpenes from marine origin
PROTEOMICS, Volume 24, Issue 10, May 2024.Abstract Pseudopteroxazole (Ptx) and the pseudopterosins are marine natural products with promising antibacterial potential. While Ptx has attracted interest for its antimycobacterial activity, pseudopterosins are active against several clinically relevant pathogens. Both compound classes exhibit low cytotoxicity and accessibility to targeted synthesis,
Niklas B. M. Janzing +6 more
wiley +1 more source
Simplified Teixobactin Analogues to Target Superbugs [PDF]
Future Medicinal Chemistry, 2017 Ishwar Singh speaks to Benjamin Walden, Commissioning Editor. Ishwar Singh is Senior Lecturer in biological chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Senior Research Fellowship, DANIDA, Denmark and CSIR, India.
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What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley +1 more source
Super‐resolution fluorescence microscopy for investigating bacterial cell biology
Molecular Microbiology, Volume 121, Issue 4, Page 646-658, April 2024.Current developments in super‐resolution fluorescence microscopy are opening up new possibilities in molecular and cellular bacteriology. The latest applications are presented including the use of MINFLUX nanoscopy for research into secretion systems.
Alexander Carsten +2 more
wiley +1 more source
OBSTRUCTION IN THE DISCOVERY OF NEW ANTIBIOTIC DRUGS:
Journal of University Medical & Dental College, 2017 : After discovery of antibiotic in 1928, there are 100 of compounds, but after 1987 no new class had been discovered. Infectious diseases are third leading cause of deaths in US and second leading cause in whole world. Obstruction in the discovery of new
Farjad Afzal, Asma Afzal, Sidra Manzoor
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