Results 51 to 60 of about 957 (147)
Teixobactin: a novel anti-infective agent [PDF]
Expert Review of Anti-infective Therapy, 2018 In 2015, a screen of bacterial strains produced a novel antibiotic with broad antimicrobial activity known as teixobactin [1].
openaire +2 more sources
Efficient total syntheses and biological activities of two teixobactin analogues
, 2016 The discovery of the new antibiotic teixobactin has been timely in the race for unearthing novel antibiotics wherein the emergence of drug resistance bacteria poses a serious threat worldwide.
Dorien Van Lysebetten (10047067) +7 more
core +3 more sources
Fluorescent Teixobactin Probes [PDF]
, 2020 Antibiotic resistant bacteria are an increasing threat to global human health. These drug resistant infections are challenging to treat and contain, and the antibiotic discovery pipeline does not match the pace of the growing number of antibiotic ...
Morris, Michael Anthony
core
Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok +11 more
wiley +2 more sources
Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis
Beilstein Journal of Organic Chemistry, 2016 Rising resistance to current clinical antibacterial agents is an imminent threat to global public health and highlights the demand for new lead compounds for drug discovery.
Darcy J. Atkinson +3 more
doaj +1 more source
TEIXOBACTIN - A GAME CHANGER ANTIBIOTIC
Era's Journal of Medical Research, 2020 Ateam of scientist under the supervision of Kim Lewis from Northeastern University has discovered a novel antibiotic called Teixobactin, which kills the bacteria by inhibiting them from building their outer protein envelop. The bacterial resistance interference are key challenges to the global health.
Sahil Hussain, Neelam Yadav
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Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin. [PDF]
, 2020 This paper describes the chemical synthesis, X-ray crystallographic structure, and antibiotic activity assay of lactam analogues of teixobactin and explores ring-expanded analogues of teixobactin with β3-homo amino acids.
Yang, Hyunjun +3 more
core +1 more source
Structure-Activity Relationship of Arg10-Teixobactin: A Recently Discovered Antimicrobial Peptide
Proceedings, 2017 The emergence of multidrug resistant bacteria has a direct impact on global public health due to the reduced potency of existing antibiotics against pathogens [1]. [...]
Fernando Albericio +8 more
doaj +1 more source
Application of iChip to Grow “Uncultivable” Microorganisms and its Impact on Antibiotic Discovery
Journal of Pharmacy & Pharmaceutical Sciences, 2015 Antibiotics have revolutionized modern medicine, allowing significant progress in healthcare and improvement in life expectancy. Development of antibiotic resistance by pathogenic bacteria is a natural phenomenon; however, the rate of antibiotic ...
Rinzhin T. Sherpa +2 more
doaj +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley +1 more source