Results 91 to 100 of about 161,718 (344)

CRISPR-based m6A modification and its potential applications in telomerase regulation

Frontiers in Cell and Developmental Biology, 2023
Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m6A epigenetic modification plays an important role in the regulation of telomerase activity.
Mingliang Yi, Mingyue Wang, Yongjie Xu, Zhikun Cao, Yinghui Ling, Yinghui Ling, Zijun Zhang, Zijun Zhang, Hongguo Cao, Hongguo Cao   +9 more
doaj   +1 more source

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]

, 2015
Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A., Goto, G.H., Henry, E., Ogi, H., Sugimoto, K., Zencir, Sevil   +5 more
core   +1 more source

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Telomerase Assay Using Biotinylated-Primer Extension and Magnetic Separation of the Products

BioTechniques, 1998
Human telomerase, a ribonucleoprotein enzyme, is known to be associated with immortalized cancer cells but is absent in most normal tissues. Thus, telomerase appears to be an attractive new target for anticancer agents and an important diagnostic marker ...
Daekyu Sun, Laurence H. Hurley, Daniel D. Von Hoff   +2 more
doaj   +1 more source

Telomerase extracurricular activities [PDF]

Proceedings of the National Academy of Sciences, 2002
The extended growth potential of cancer cells is critically dependent upon the maintenance of functional telomeres, G-rich repeat sequences that cap the ends of most eukaryotic chromosomes and serve to protect natural DNA ends from being recognized as double-stranded breaks (reviewed in ref. 1).
Sandy, Chang, Ronald A, DePinho
openaire   +2 more sources

Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models. [PDF]

, 2015
Malignant melanoma requires precise resection in order to avoid metastatic recurrence. We report here that the telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401 could label malignant melanoma with GFP in situ in ...
Bouvet, Michael, Fujiwara, Toshiyoshi, Hoffman, Robert M, Kagawa, Shunsuke, Kishimoto, Hiroyuki, Takehara, Kiyoto, Urata, Yasuo, Yano, Shuya   +7 more
core   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

SMN and coilin negatively regulate dyskerin association with telomerase RNA

Biology Open, 2016
Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins.
Aaron R. Poole, Michael D. Hebert
doaj   +1 more source

Hydroxyapatite promotes superior adhesion and proliferation of telomerase transformed keratocytes in comparison with inert plastic skirt materials used in leading contemporary keratoprostheses [PDF]

, 2005
Aim: Published clinical series suggest the osteoodontokeratoprosthesis (OOKP) may have a lower extrusion rate than current synthetic keratoprostheses. The OOKP is anchored in the eye wall by autologous tooth.
Allen, B.D.S., Faragher, R.G.A.F., Futter, C., Hing, K.A., Mehta, J., Sandeman, S.R., Tanner, K.E.   +6 more
core   +2 more sources

Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT)

International Journal of Molecular Sciences, 2018
Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple rounds of replications. During tumorigenesis, cells have to acquire telomere DNA maintenance mechanisms (TMMs) in order to counteract telomere shortening, to preserve ...
M. de Vitis, F. Berardinelli, A. Sgura
semanticscholar   +1 more source