Results 131 to 140 of about 161,718 (344)

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Supplementary Data 1 from Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial

, 2023
Espen B. Ellingsen, Steven O’Day, Artur Mezheyeuski, Agnieszka Gromadka, Trevor Clancy, Timothy S. Kristedja, Mohammed Milhem, Yousef Zakharia   +7 more
openalex   +1 more source

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2000
Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay   +5 more
doaj   +1 more source

Exploring Telomerase Activity at Single-Cell Level Based on Sers and Fluorescence Dual-Channel Microfluidic Droplet Platform

, 2022
Guohua Qi, Xuan Yi, Minmin Wang, Hongyan Zhu, Zhuoming Liu   +4 more
openalex   +1 more source

Structure of active human telomerase with telomere shelterin protein TPP1

Nature, 2022
Baocheng Liu, Yao He, Yaqiang Wang, He Song, Z. Zhou, J. Feigon   +5 more
semanticscholar   +1 more source

Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells

Open Biology, 2017
Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal.
C. Armstrong, K. Tomita
semanticscholar   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Telomerase [PDF]

, 2006
Maria Antonietta Cerone, Silvia Bacchetti   +1 more
  +5 more sources

Development of a microarray based telomerase binding assay reveals unusual binding of a cytochalasin derivative

Scientific Reports
Telomerase reverse transcriptase is crucial for cellular development, regeneration, and disease processes. Strategies for both telomerase activation and inhibition have been intensively explored in the past decades.
Jia Li Ye, Lu Fan, Christian Bär, Thomas Thum, Oliver Plettenburg, Russell J. Cox, Carsten Zeilinger   +6 more
doaj   +1 more source

Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

eLife, 2016
We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways.
Jacob M Vogan, Xiaozhu Zhang, Daniel T Youmans, Samuel G Regalado, Joshua Z Johnson, Dirk Hockemeyer, Kathleen Collins   +6 more
doaj   +1 more source