Results 151 to 160 of about 161,718 (344)

Telomerase Is Processive [PDF]

Molecular and Cellular Biology, 1991
Telomerase synthesizes tandem repeats of the sequence d(TTGGGG) onto input d(TTGGGG)n primer oligonucleotides (C. W. Greider and E. H. Blackburn, Cell 43:405-413). An intrinsic RNA component of the enzyme provides the template for d(TTGGGG)n repeat synthesis [C. W. Greider and E. H. Blackburn, Nature (London) 337:331-337, 1989; G.-L. Lu, J. D. Bradley,
openaire   +2 more sources

hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer [PDF]

Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
Blake, JRS, Elkak, AE, Meligonis, G, Mitchell, B, Mokbel, K, Newbold, RF, Salhab, M   +6 more
core   +3 more sources

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

The role of telomere and telomerase in cancer and novel therapeutic target: narrative review

Frontiers in Oncology
Telomeres are dynamic complexes at the ends of chromosomes that are made up of protective proteins and tandem repeating DNA sequences. In the large majority of cancer cells, telomere length is maintained by telomerase, an enzyme that elongates telomeres.
Temesgen Baylie, Mohammed Jemal, Gelagay Baye, Mamaru Getinet, Gashaw Azanaw Amare, Adane Adugna, Desalegn Abebaw, Zigale Hibstu, Bantayehu Addis Tegegne, Endalkachew Gugsa, Tadegew Adane, Gedefaw Getie, Baye Ashenef, Deresse Sinamaw   +13 more
doaj   +1 more source

No end in sight for telomerase-targeted cancer drugs [PDF]

, 2013
Sarah Williams
openalex   +1 more source

Regulation of human telomerase in homeostasis and disease

Nature reviews. Molecular cell biology, 2020
Caitlin M. Roake, S. Artandi
semanticscholar   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Potential of telomerase expression and activity in cervical specimens as a diagnostic tool [PDF]

, 2005
Sara Bravaccini, Maria Aurora Sanchini, Andrea Amadori, Laura Medri, Luca Saragoni, Daniele Calistri, Franco Monti, Annalisa Volpi, D. Amadori   +8 more
openalex   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

Preparation and Characterization of Candidate Reference Materials for Telomerase Assays [PDF]

, 2005
John P. Jakupciak, Peter E. Barker, Wendy Wang, Sudhir Srivastava, Donald H. Atha   +4 more
openalex   +1 more source