Role of Telomeres and Telomerase in Aging and Cancer.
Cancer Discovery, 2016 J. Shay
semanticscholar +1 more source
Genetic variants underlying precancerous conditions of hepatocellular carcinoma
International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero +7 more
wiley +1 more source
Retraction: Cytokines Modulate Telomerase Activity in a Human Multiple Myeloma Cell Line [PDF]
Masaharu Akiyama +9 more
openalex +1 more source
New cell lines expanding the diversity of Ewing sarcoma models
International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff +13 more
wiley +1 more source
YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction. [PDF]
Aging CellCheng X +16 more
europepmc +1 more source
Telomerase-based circulating tumor cell detection for treatment response prediction in patients with non-small-cell lung cancer [PDF]
Issei Sumiyoshi +13 more
openalex +1 more source
Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA [PDF]
, 2011 Natalia A. Denesyuk, D. Thirumalai
openalex +1 more source
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source