Results 51 to 60 of about 161,718 (344)

KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]

, 2017
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao, Deng, Wuguo, Fu, Xiaoyan, Gao, Fan, Huang, Wenlin, Kang, Lan, Li, Wenbin, Li, Yixin, Liu, Tianze, Qin, Ge, Shi, Dingbo, Shi, Fen, Song, Chen, Tang, Bing, Tang, Ranran, Wu, Xiaojun, Xiao, Binyi, Xiao, Xiangsheng, Zhang, Changlin   +18 more
core   +1 more source

The Rate of Increase of Short Telomeres Predicts Longevity in Mammals

Cell Reports, 2012
Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice present high interindividual variation in telomere length, but it is unknown whether this is ...
Elsa Vera, Bruno Bernardes de Jesus, Miguel Foronda, Juana M. Flores, Maria A. Blasco   +4 more
doaj   +1 more source

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Genome Medicine, 2016
Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase.
M. Jafri, S. Ansari, M. Alqahtani, J. Shay   +3 more
semanticscholar   +1 more source

Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models

iScience, 2019
Summary: Telomeres are considered potential anti-cancer targets. Most studies have focused on telomerase inhibition, but this strategy has largely failed in clinical trials.
Leire Bejarano, Jessica Louzame, Juán José Montero, Diego Megías, Juana M. Flores, Maria A. Blasco   +5 more
doaj   +1 more source

There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer [PDF]

, 2004
Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kirkpatrick, KL, Mokbel, K, Newbold, RF
core   +2 more sources

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

EMBO Molecular Medicine, 2012
A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity.
Bruno Bernardes de Jesus, Elsa Vera, Kerstin Schneeberger, Agueda M. Tejera, Eduard Ayuso, Fatima Bosch, Maria A. Blasco   +6 more
doaj   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple-Gene Approach: Mutant CDK4, Cyclin D1, and TERT. [PDF]

Cell Biol Int
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Bai L, Takahashi M, Kobayashi J, Eitsuka T, Matsusaka H, Ozaki T, Sugano E, Tomita H, Xu Y, Kawamura K, Nakagawa K, Kiyono T, Fukuda T.   +12 more
europepmc   +2 more sources

A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase [PDF]

Nature Structural & Molecular Biology, 2005
Telomerase maintains the simple sequence repeats at chromosome ends, protecting cells from genomic rearrangement, proliferative senescence and death. The telomerase reverse transcriptase (TERT) and telomerase RNA (TER) alone can assemble into active enzyme in a heterologous cell extract, but the physiological process of telomerase biogenesis is more ...
Ramadevi, Prathapam, Keren L, Witkin, Catherine M, O'Connor, Kathleen, Collins   +3 more
openaire   +2 more sources

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

The regulations of telomerase reverse transcriptase (TERT) in cancer

Cell Death and Disease
Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu, Yuning Zhang, Yongping Jian, Liting Gu, Dan Zhang, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu   +7 more
semanticscholar   +1 more source