Results 71 to 80 of about 161,718 (344)

The role of telomeres and telomerase in the clinical effect and mechanism of action of psychopharmacological interventions [PDF]

, 2017
Originally studied in relation to aging and cancer research, telomeres and telomerase are now also investigated in relation to psychiatric disorders and treatments.
Bersani, F. S.
core  

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
Achi, Aitken, Allsopp, Bailey, Baird, Betts, Blackburn, Cerone, de La Roche Saint-Andre, Dozortsev, Edwards, Evenson, Fiorenza, Fulka, G. M. Hartshorne, Gonzalo, H. P. Wong, Holt, Huang, J. Rai, Keefe, Keefe, Kimura, Lassalle, Liu, Liu, Liu, Longo, McIlrath, Meerdo, Morelli, Murnane, Rodr  guez, S. Turner, Schaetzlein, Tesarik, Valdes, Whitmire, Wong, Wright, Xu, Zhivkova, Zijlmans   +42 more
core   +2 more sources

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

Nature, 2018
Hepatocytes are replenished gradually during homeostasis and robustly after liver injury1, 2. In adults, new hepatocytes originate from the existing hepatocyte pool3–8, but the cellular source of renewing hepatocytes remains unclear.
Shengda Lin, Elisabete M. Nascimento, Chandresh R. Gajera, Lu Chen, P. Neuhoefer, A. Garbuzov, Sui Wang, S. Artandi   +7 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

Nature Communications, 2018
Long non-coding RNA TERRAs are essential for telomere protection and telomere length maintenance. Here the authors report a role for TERRAs in telomeric heterochromatin formation by recruiting Polycomb Repressive Complex 2 to telomeres.
Juan J. Montero, Isabel López-Silanes, Diego Megías, Mario F. Fraga, Álvaro Castells-García, Maria A. Blasco   +5 more
doaj   +1 more source

Interleukin 8 is a biomarker of telomerase inhibition in cancer cells

BMC Cancer, 2018
Background Telomerase activity is required for both initiation and maintenance of tumorigenesis and over 90% cancers overexpress telomerase. Therefore, telomerase targeting has emerged as a potential strategy for cancer treatment. In agreement with this,
Peter Solomon, Yuying Dong, Shaillay Dogra, Romi Gupta   +3 more
doaj   +1 more source

Cell proliferation in the presence of telomerase. [PDF]

PLoS ONE, 2009
BACKGROUND: Telomerase, which is active early in development and later in stem and germline cells, is also active in the majority of human cancers. One of the known functions of telomerase is to extend the ends of linear chromosomes, countering their ...
Krastan B Blagoev
doaj   +1 more source

Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia [PDF]

, 2017
Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability.
Bezares, Raimundo F., Dos Santos, Patricia Carolina, Palau Nagore, Maria Virginia, Panero, Julieta, Slavutsky, Irma Rosa, Stanganelli, Carmen Graciela, Stella, Flavia   +6 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

Cell Reports, 2015
Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2–3 years. New therapeutic targets and treatments are necessary.
Juan M. Povedano, Paula Martinez, Juana M. Flores, Francisca Mulero, Maria A. Blasco   +4 more
doaj   +1 more source