The correlation between telomerase activity and BaX/BcL-2 ratio in valproic acid-treated MCF-7 breast cancer cell line [PDF]
, 2015 Objective(s): Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms.
Asadi, J., Gharaei, R., Vafaiyan, Z.
core +2 more sources
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
core +1 more source
Advanced Science, EarlyView.A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang +14 more
wiley +1 more source
Current Insights to Regulation and Role of Telomerase in Human Diseases
Antioxidants, 2017 The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells.
Mert Burak Ozturk +2 more
doaj +1 more source
CRISPR-based m6A modification and its potential applications in telomerase regulation
Frontiers in Cell and Developmental Biology, 2023 Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m6A epigenetic modification plays an important role in the regulation of telomerase activity.
Mingliang Yi +9 more
doaj +1 more source
Telomerase extracurricular activities [PDF]
Proceedings of the National Academy of Sciences, 2002 The extended growth potential of cancer cells is critically dependent upon the maintenance of functional telomeres, G-rich repeat sequences that cap the ends of most eukaryotic chromosomes and serve to protect natural DNA ends from being recognized as double-stranded breaks (reviewed in ref. 1).
Sandy, Chang, Ronald A, DePinho
openaire +2 more sources
Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]
, 2005 The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati +64 more
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Advanced Science, EarlyView.Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang +9 more
wiley +1 more source
Telomerase Assay Using Biotinylated-Primer Extension and Magnetic Separation of the Products
BioTechniques, 1998 Human telomerase, a ribonucleoprotein enzyme, is known to be associated with immortalized cancer cells but is absent in most normal tissues. Thus, telomerase appears to be an attractive new target for anticancer agents and an important diagnostic marker ...
Daekyu Sun +2 more
doaj +1 more source
Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence. [PDF]
, 2016 We have previously developed a genetically-engineered GFP-expressing telomerase-dependent adenovirus, OBP-401, which can selectively illuminate cancer cells.
Bouvet, Michael +9 more
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