Telomerase reverse transcriptase and neurodegenerative diseases [PDF]
Frontiers in Immunology, 2023 Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS).
Xin Yu +5 more
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Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation [PDF]
Biomedicines, 2023 Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template.
Anastasia I. Palamarchuk +2 more
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The regulations of telomerase reverse transcriptase (TERT) in cancer [PDF]
Cell Death and DiseaseAbnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu +7 more
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Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutations. [PDF]
Front Cell Dev Biol, 2023 Telomerase activity and telomere elongation are essential conditions for the unlimited proliferation of neoplastic cells. Point mutations in the core promoter region of the telomerase reverse transcriptase (TERT) gene have been found to occur at high ...
Tornesello ML +8 more
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Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer. [PDF]
Cell Commun Signal, 2023 Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of telomerase, a crucial enzyme responsible for telomere maintenance and human genome stability.
Yang R +7 more
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LARP7 family proteins have conserved function in telomerase assembly [PDF]
Nature Communications, 2018 The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.
Laura C. Collopy +11 more
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Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage [PDF]
PeerJ, 2022 Background Angiogenesis is an endogenous repair mechanism following hypoxic-ischemic brain damage (HIBD). Interestingly, recent studies have shown that angiogenesis can be regulated by telomerase reverse transcriptase (TERT), a critical component of ...
Jiao Li +4 more
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer [PDF]
Journal of Biomedical Sciences, 2018 BackgroundLimitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
Ricardo Leão +5 more
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In silico prediction of telomerase reverse transcriptase inhibitors using modified retinol for the treatment of arsenical cancer [PDF]
Bangabandhu Sheikh Mujib Medical University Journal, 2016 Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Kipchu Tshering, Mir Misbahuddin
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Diverse regulatory manners of human telomerase reverse transcriptase
Cell Communication and Signaling, 2019 Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation,
Meng-Meng Jie +9 more
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