Results 111 to 120 of about 128,505 (270)

Telomerase Induction in HPV Infection and Oncogenesis

Viruses, 2017
Telomerase extends the repetitive DNA at the ends of linear chromosomes, and it is normally active in stem cells. When expressed in somatic diploid cells, it can lead to cellular immortalization. Human papillomaviruses (HPVs) are associated with and high-
Rachel Katzenellenbogen
doaj   +1 more source

Tel1ATM dictates the replication timing of short yeast telomeres [PDF]

, 2014
Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins.
Alessandro Bianchi, Anoushka Davé, Carol Cooley, Mansi Garg, Ritchie KB   +4 more
core   +2 more sources

Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

Frontiers in Genetics, 2016
Chromosome-shortening is characteristic of normal cells, and is known as the end replication problem. Telomerase is the enzyme responsible for extending the ends of the chromosomes in de novo synthesis, and occurs in germ cells as well as most malignant ...
Kayla A Lewis, T. Tollefsbol
semanticscholar   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Current Insights to Regulation and Role of Telomerase in Human Diseases

Antioxidants, 2017
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells.
Mert Burak Ozturk, Yinghui Li, Vinay Tergaonkar   +2 more
doaj   +1 more source

Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease

Scientific Reports, 2016
Activation of Kupffer cells (KCs) plays a central role in the pathogenesis of alcoholic liver disease (ALD). C57BL/6 mice fed EtOH-containing diet showed a mixed induction of hepatic classical (M1) and alternative (M2) macrophage markers.
Xiao-qin Wu, Yang Yang, Wan-xia Li, Yahui Cheng, Xiao-Feng Li, Cheng Huang, Xiao-ming Meng, Bao‐ming Wu, Xinhua Liu, Lei Zhang, Xiongwen Lv, Jun Li   +11 more
semanticscholar   +1 more source

Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age‐related processes leading to Porphyr'ageing

International Journal of Cosmetic Science, EarlyView.
Porphyrins, previously linked only to acne inflammation, are now implicated in skin ageing. Their presence correlates with increased melanin, inflammation, and oxidative stress, contributing to premature ageing signs. This study introduces the concept of “Porphyr'ageing,” highlighting the detrimental effects of bacterial metabolites on skin health and ...
Marie Meunier, Morgane De Tollenaere, Cyrille Jarrin, Emilie Chapuis, Marine Bracq, Laura Lapierre, Catherine Zanchetta, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +9 more
wiley   +1 more source

Evaluation of telomerase expression in chronic periodontitis

Indian Journal of Dental Research, 2010
Background : Human telomerase is a multi subunit ribonucleoprotein enzyme concerned with telomeric lengthening and homeostasis in man. This enzyme has been found to be elevated in inflammatory conditions like rheumatoid arthritis and silica injury lung ...
Balaji T, Vettriselvi V, Paul Solomon, Rao Suresh   +3 more
doaj  

Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase

Nucleic Acids Research, 2017
The elongation of single-stranded DNA repeats at the 3′-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes.
O. A. Petrova, Alexey B. Mantsyzov, E. Rodina, S. Efimov, C. Hackenberg, J. Hakanpää, V. Klochkov, A. A. Lebedev, A. Chugunova, A. Malyavko, T. Zatsepin, A. Mishin, Maria I Zvereva, V. Lamzin, O. Dontsova, V. Polshakov   +15 more
semanticscholar   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source