Expression of hTERT mRNA in Anip973 and Anip973/NVB Cell Detected by Quantitative Real-time PCR
Chinese Journal of Lung Cancer, 2010 Background and objective Human telomerase reverse transcriptase is the catalytic subunit of telomerase, and its activity is correlated with cell’s sensitivity to chemotherapy.
Jingjing LIU, Shuying GUO, Gongyan CHEN
doaj
Circulating Cell‐Free DNA Concentration as a Biomarker in Head and Neck Cancer
Oral Diseases, EarlyView.ABSTRACT Objective Head and neck squamous cell carcinoma (HNSCC), particularly human papillomavirus (HPV) ‐negative HNSCC, poses a significant clinical challenge due to late diagnoses and poor survival. This study evaluates the potential of circulating cell‐free DNA (ccfDNA) as a minimally invasive biomarker for diagnosis, prognosis and disease ...
Ana María Rodríguez‐Ces +7 more
wiley +1 more source
The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
Journal of Nucleic Acids, 2010 Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria.
Donna M. Gordon, Janine Hertzog Santos
doaj +1 more source
Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
, 2017 A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro +4 more
core +2 more sources
Dual-region-based computed tomography radiomics analysis for the non-invasive prediction of telomerase reverse transcriptase status and clinical prognosis in liver cancer [PDF]
, 2023 Yong Zhou +3 more
openalex +1 more source
The Outcome of Intracellular Selenomonas sputigena and its Impact on Gingival Keratinocytes
Molecular Oral Microbiology, EarlyView.ABSTRACT Selenomonas sputigena is an understudied oral pathobiont associated with periodontitis and dental caries. We recently demonstrated that S. sputigena binds to gingival epithelial cells (GECs), where afterwards the bacterium causes robust in vitro pro‐inflammatory cytokine production and migration of monocytes and neutrophils.
Colin G. Hawkes +6 more
wiley +1 more source
Medical genetics and epigenetics of telomerase [PDF]
, 2011 Telomerase is a specialized reverse transcriptase that extends and maintains the terminal ends of chromosomes, or telomeres. Since its discovery in 1985 by Nobel Laureates Elizabeth Blackburn and Carol Greider, thousands of articles have emerged ...
Fox, Melanie J. +4 more
core +1 more source
Supplementary Table 2 from PAX8 Regulates Telomerase Reverse Transcriptase and Telomerase RNA Component in Glioma [PDF]
, 2023 Yu-Jen Chen +6 more
openalex +1 more source
Human Specific Regulation of the Telomerase Reverse Transcriptase Gene
Genes, 2016 Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue homeostasis by maintaining telomere length.
Fan Zhang +3 more
semanticscholar +1 more source