Results 11 to 20 of about 128,505 (270)

Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells

Scientific Reports, 2017
Cisplatin is one of the most efficacious antimitotic drugs used in the treatment of a range of malignant tumors. However, treatment failures are common due to the development of chemoresistance.
Zhengpei Zhang, Ling Yu, Guo Dai, Kezhou Xia, Gaiwei Liu, Qi Song, Chunjie Tao, Tian Gao, Weichun Guo   +8 more
doaj   +2 more sources

Comment on "telomerase reverse transcriptase rs2736098 and rs2736100 in bladder cancer". [PDF]

Rep Pract Oncol Radiother, 2023
Mungmunpuntipantip R, Wiwanitkit V.
europepmc   +3 more sources

The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMM^Δ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity. [PDF]

Front Aging
Basu K.
europepmc   +3 more sources

Electroacupuncture pretreatment preserves telomerase reverse transcriptase function and alleviates postoperative cognitive dysfunction by suppressing oxidative stress and neuroinflammation in aged mice

CNS Neuroscience & Therapeutics, 2023
Elderly patients often exhibit postoperative cognitive dysfunction (POCD), a postsurgical decline in memory and executive function. Oxidative stress and neuroinflammation, both pathological characteristics of the aged brain, contribute to this decline ...
Wen Wang, Cheng Chen, Qiang Wang, Jiguang Ma, Yansong Li, Zheng Guan, Rui Wang, Xin Chen   +7 more
semanticscholar   +1 more source

In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs. [PDF]

PLoS ONE, 2012
Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie, Naresh R Thumati, Hélène C F Côté, Judy M Y Wong   +3 more
doaj   +1 more source

Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function

Circulation, 2021
Supplemental Digital Content is available in the text. Background: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), has protective functions in the cardiovascular system.
Niloofar Ale-Agha, P. Jakobs, C. Goy, Mark Zurek, Julia Rosen, Nadine Dyballa-Rukes, S. Metzger, Jan Greulich, Florian von Ameln, Olaf Eckermann, K. Unfried, Fedor Brack, M. Grandoch, M. Thielmann, M. Kamler, N. Gedik, P. Kleinbongard, A. Heinen, G. Heusch, A. Gödecke, J. Altschmied, J. Haendeler   +21 more
semanticscholar   +1 more source

TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly

Cell Reports, 2023
Summary: Localization of a variety of RNAs to non-membrane-bound cellular compartments such as nucleoli and Cajal bodies is critical for their stability and function.
Basma M. Klump, Gloria I. Perez, Eric M. Patrick, Kate Adams-Boone, Scott B. Cohen, Li Han, Kefei Yu, Jens C. Schmidt   +7 more
doaj   +1 more source

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia

Genes, 2021
The proliferative capacity and continuous survival of cells are highly dependent on telomerase expression and the maintenance of telomere length. For this reason, elevated expression of telomerase has been identified in virtually all cancers, including ...
Mot Yee Yik, Adam Azlan, Yaashini Rajasegaran, A. Rosli, N. Yusoff, E. Moses   +5 more
semanticscholar   +1 more source

Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]

Jichu yixue yu linchuang, 2021
Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
doaj  

A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis

Nature Communications, 2022
Most eukaryotes maintain telomeres using a specialized reverse transcriptase. Here the authors report that Thc1 (Telomerase Holoenzyme Component 1) and Bmc1 (Bin3/MePCE 1) form a complex with Pof8, a constitutive member of telomerase in fission yeast.
Diego J. Páez-Moscoso, David V. Ho, Lili Pan, Katie Hildebrand, Kristi L. Jensen, Michaella J. Levy, Laurence Florens, Peter Baumann   +7 more
doaj   +1 more source