Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]
, 2020 Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core +1 more source
Frontiers in Oncology, 2012 Telomerase is a highly specialized reverse transcriptase and the maintenance of telomeric length is determined by this specific enzyme. The human holoenzyme telomerase is a ribonucleoprotein composed by a catalytic subunit, hTERT, an RNA component, hTR ...
Daniel E Gomez +2 more
doaj +1 more source
CDK1 dependent phosphorylation of hTERT contributes to cancer progression
Nature Communications, 2020 Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa +18 more
doaj +1 more source
Is telomerase reactivation associated with the down-regulatoin of TGFβ receptor-II expression in human breast cancer? [PDF]
, 2003 Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Elkak, AE +3 more
core +3 more sources
Insertion of retrotransposons at chromosome ends: adaptive response to chromosome maintenance
Frontiers in Genetics, 2016 The telomerase complex is a specialized reverse transcriptase that inserts tandem DNA arrays at the linear chromosome ends and contributes to the protection of the genetic information in eukaryotic genomes.
Geraldine eServant, Prescott L Deininger
doaj +1 more source
Cancer-associated TERT promoter mutations abrogate telomerase silencing. [PDF]
, 2015 Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Boyle, John +5 more
core +1 more source
A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.
PLoS Biology, 2019 Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells.
Wilnelly Hernandez-Sanchez +8 more
doaj +1 more source
The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression [PDF]
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation.
Kirkpatrick, KL, Mokbel, K, Newbold, RF
core +3 more sources
Future Journal of Pharmaceutical Sciences, 2021 Background Telomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover novel and more effective anticancer agents.
R. D. Jawarkar +6 more
doaj +1 more source
The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids. [PDF]
, 2015 Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN)
Akiyama, Benjamin M +2 more
core +2 more sources