Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]
, 2018 The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea +4 more
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AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model [PDF]
, 2016 Limitless replicative potential is one of the hallmarks of cancer that is mainly due to the activity of telomerase. This holoenzyme maintains telomere length, adding TTAGGG repetitions at the end of chromosomes in each cell division.
Armando, Romina Gabriela +2 more
core +1 more source
NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. [PDF]
, 2017 N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of
Chen, Yiming +15 more
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Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast
Nature Communications, 2018 The core of the telomerase holoenzyme is composed of the reverse transcriptase and the non-coding RNA template. Here the authors identify Pof8 as a new constitutive component of fission yeast telomerase, loss of which causes telomerase assembly defects ...
Diego J. Páez-Moscoso +5 more
doaj +1 more source
Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. [PDF]
PLoS Genetics, 2011 The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known ...
Jonathan K Alder +9 more
doaj +1 more source
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
International Journal of Molecular Sciences, 2019 Telomerase, an RNA-dependent DNA polymerase with telomerase reverse transcriptase (TERT) as the catalytic component, is silent due to the tight repression of the TERT gene in most normal human somatic cells, whereas activated only in small subsets of ...
Xiaotian Yuan, Dawei Xu
semanticscholar +1 more source
Haematologica, 2012 Background Chronic idiopathic neutropenia is characterized by immune-mediated suppression of neutrophil production. Because patients with immune-mediated bone marrow failure syndromes display age-inappropriate telomere shortening in leukocytes, we ...
Konstantia I. Pavlaki +5 more
doaj +1 more source
Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]
, 2016 open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea +6 more
core +1 more source
Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia [PDF]
, 2017 Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability.
Bezares, Raimundo F. +6 more
core +1 more source
Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases
Biomedicines, 2021 Telomerase is an enzyme that in its canonical function extends and maintains telomeres, the ends of chromosomes. This reverse transcriptase function is mainly important for dividing cells that shorten their telomeres continuously.
Gabriele Saretzki, Tengfei Wan
doaj +1 more source