Results 281 to 290 of about 77,771 (318)
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Telomere-binding proteins of Arabidopsis thaliana
Plant Molecular Biology, 1995The nucleoprotein structure of Arabidopsis thaliana telomeres was investigated. A protein specifically binding to telomeric sequences was characterized by gel mobility shift assays with synthetic oligonucleotides consisting of four 7 bp telomeric repeats of Arabidopsis (TTTAGGG) and crude nuclear protein extracts of Arabidopsis leaves.
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Purification of a telomere-binding protein from Physarum polycephalum
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992We have purified a telomere-binding protein (PPT) from the acellular slime mold Physarum polycephalum. As shown previously (Coren, J.S., Epstein, E.M. and Vogt, V.M. (1991) Mol. Cell. Biol. 11, 2282-2290), in vitro this protein binds specifically to the double stranded (TTAGGG)n repeats that are found at the telomeres of extrachromosomal ribosomal DNA ...
J S, Coren, V M, Vogt
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Using the Telobox to Search for Plant Telomere Binding Proteins
Current Protein & Peptide Science, 2011Telobox is a Myb-related DNA-binding domain which is present in a number of yeast, plant and animal proteins. Its capacity to bind preferentially double-stranded telomeric DNA has been used in numerous studies to search for candidate telomeric proteins in various organisms, including plants.
Vratislav, Peška +2 more
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Human telomeric binding proteins recognizing single and double stranded DNA
International Journal of Oncology, 1996Telomeres of human chromosomes consist of a repeated TTAGGG sequence, and at the terminal of this repeat sequence, the 3' strand is longer than the 5' strand. In this study, we characterized single and double stranded telomere binding proteins (ssTBPs and dsTBPs) by gel mobility shift assay and South-Western blotting assay.
K, Matsuo +4 more
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G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014Telomere is protected by its G-quadruplex, T-loop structure, telomerase, and binding protein complex. Protein POT1 (protection of telomeres 1) is one subunit of telomere binding protein complex Shelterin. POT1 acts as a regulator of telomerase-dependent telomere length, and it can help telomere to form D-loop structure to stabilize telomere.
Qingqing He +6 more
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Telomere-Binding Proteins in Humans
2009Shelterin, the telomere-secific protein complex, is essential for genome stability and cell viability. Shelterin accumulates at telomeres and transforms chromosome ends into specialized structures that evade recognition by the DNA damage signaling and repair machineries and are maintained through consecutive cell divisions. Shelterin accomplishes these
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Telomere-binding Proteins in Fission Yeast
2006The telomere is a specialized heterochromatin localized at the end of the linear chromosome, and is essential for the multiple aspects of genome integrity. Telomere functions are performed mostly by telomere-binding proteins. Although many of the telomere-binding proteins are conserved among species, some variations exist. Recent studies of the fission
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Telomere-Binding Proteins of Ciliated Protozoa
1995A great deal of our current knowledge about telomere structure and function has come from studies performed with ciliated protozoa. The reason that studies of ciliate telomeres have been so productive stems from the unusual genomic organization of these organisms.
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The Micronuclear Gene Encoding β‐Telomere Binding Protein in Oxytricha nova
Journal of Eukaryotic Microbiology, 1994ABSTRACT The micronuclear version of the gene encoding β‐telomere binding protein (β‐TBP) in Oxytricha nova has been sequenced and compared to the macronuclear β‐TBP gene, previously described. The micronuclear gene contains three AT‐rich internal eliminated sequences (IES) of 37, 40, and 43 bp and four macronuclear destined sequences (MDS).
J L, Mitcham, D M, Prescott, M K, Miller
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The levels of telomere-binding proteins in human tumours and therapeutic implications
European Journal of Cancer, 2009Tumours require telomeric integrity to maintain viability, conferred by adequate length of telomeric DNA replenished by telomerase, and binding of telomere-binding proteins (TBPs), thus telomeres have received attention as an anticancer target. Levels of TBPs in tumour tissue may have implications for drug development if they render some cancers ...
J C, Cookson, C A, Laughton
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