Results 111 to 120 of about 110,609 (302)

The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review

Current Issues in Molecular Biology
HIV and parasite infections accelerate biological aging, resulting in immune senescence, apoptosis and cellular damage. Telomere length is considered to be one of the most effective biomarkers of biological aging.
Engelinah D. Macamo, Zilungile L. Mkhize-Kwitshana, Julian Mthombeni, Pragalathan Naidoo   +3 more
doaj   +1 more source

Aging and Immortality in a Cell Proliferation Model

, 2008
We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres ...
Abramowitz, Bailey, Bailey, Bryan, Campisi, Campisi, Campisi, Carey, Fleming, Gikhman, Gradshteyn, Harley, Hasenmaile, Hayflick, Henson, K.B. Blagoev, Karlin, Nisbet, Olovnikov, Reddel, Redner, S. Redner, S.A. Trugman, Steinsaltz, T. Antal, Watson, Weitz   +26 more
core   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Effects of brood size manipulation and common origin on phenotype and telomere length in nestling collared flycatchers

BMC Ecology, 2012
Background Evidence is accumulating that telomere length is a good predictor of life expectancy, especially early in life, thus calling for determining the factors that affect telomere length at this stage. Here, we investigated the relative influence of
Voillemot Marie, Hine Kathryn, Zahn Sandrine, Criscuolo François, Gustafsson Lars, Doligez Blandine, Bize Pierre   +6 more
doaj   +1 more source

Mediterranean diet and telomere length

BMJ, 2014
Genetic factors may contribute to the link between Mediterranean diet and longer telomeres Interest in telomere biology has increased in recent years, both because of the quest for a reliable marker of biological ageing and because shorter telomeres in leucocytes have been shown to predict coronary heart disease (CHD).1 2 The methodological challenges
openaire   +4 more sources

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Influence of In Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Prostate Cancer, 2016
Background. Modifiable factors in adulthood that explain the racial disparity in prostate cancer have not been identified. Because racial differences in utero that may account for this disparity are understudied, we investigated the association of ...
Kari A. Weber, Christopher M. Heaphy, Sabine Rohrmann, Beverly Gonzalez, Jessica L. Bienstock, Tanya Agurs-Collins, Elizabeth A. Platz, Alan K. Meeker   +7 more
doaj   +1 more source

The role of telomeres and telomerase in the clinical effect and mechanism of action of psychopharmacological interventions [PDF]

, 2017
Originally studied in relation to aging and cancer research, telomeres and telomerase are now also investigated in relation to psychiatric disorders and treatments.
Bersani, F. S.
core  

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs [PDF]

, 2013
Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length.
A Canela, A Golubev, A Kowald, AE Bilsland, AJ Cesare, AJ Zaug, AM Zahler, Bartholomäus V. Hirt, BV Hirt, C Leonetti, C Schaffitzel, CJ Proctor, CJ Proctor, D Monchaud, E Henderson, EH Blackburn, F Wang, G Cristofari, G Wallweber, H Takai, HJ Lipps, I Rubelj, IA Rodriguez-Brenes, IA Sidorov, J Grasman, J Tang, JAD Wattis, JC Cookson, JD Griffith, Jonathan A. D. Wattis, K Masutomi, K Monier, KB Blagoev, L Hayflick, L Hayflick, L Oganesian, LA Johnson, M Gunaratnam, M Kimura, M Lei, M Macville, MA Collins, MK Cheng, MT Hemann, MT Teixeira, MZ Levy, N Arkus, NW Kim, O Arino, O Samassekou, O Wolkenhauer, P Abdallah, P Olofsson, P Olofsson, P Rosenau, P Wu, PD Sozou, PV Dmitriev, R Milo, RA Greenberg, RA Heald, RC Allsopp, S Neidle, SB Cohen, Simon P. Preston, SLB Knig, SM Gowan, SN Saldanha, SSS Poon, T Antal, T Lange de, T Lange de, T Lange de, T Richter, T Tauchi, T Zglinicki von, UM Martens, VL Makarov, W Palm, WE Wright, XY Dai, Y Xu, Y Zhao, Y Zhao   +83 more
core   +3 more sources

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source