Results 71 to 80 of about 110,609 (302)

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study

Clinical Epigenetics
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross, Benjamin J. Varley, Jadon K. Wells, Robyn P. L. Yeh, Hilda A. Pickett, Raja S. Vasireddy, Lynne Roberts, Greg Davis, Amanda Henry, Maria E. Craig, Megan L. Gow   +10 more
doaj   +1 more source

Longer telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.

PLoS ONE, 2014
Oxidative stress is involved in the pathogenesis of airway obstruction in α1-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence.
Aabida Saferali, Jee Lee, Don D Sin, Farshid N Rouhani, Mark L Brantly, Andrew J Sandford   +5 more
doaj   +1 more source

Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes. [PDF]

, 2016
Telomeres, the protective DNA-protein complexes at the ends of linear chromosomes, are important for genome stability. Leukocyte or peripheral blood mononuclear cell (PBMC) telomere length is a potential biomarker for human aging that integrates genetic,
Aschbacher, Kirstin, Blackburn, Elizabeth H, Brown, Rashida, Cheon, Joshua, Coccia, Michael, Epel, Elissa, Lin, Jue, Puterman, Eli, Sinclair, Elizabeth   +8 more
core   +3 more sources

Telomere length in human blastocysts [PDF]

Reproductive BioMedicine Online, 2014
This is a retrospective study aiming to assess telomere length in human embryos 4 days post fertilization and to determine whether it is correlated to chromosomal ploidy, embryo developmental rate and patient age. Embryos were donated from patients undergoing treatment in the assisted conception unit.
Anastasia, Mania, Anna, Mantzouratou, Joy D A, Delhanty, Gianluca, Baio, Paul, Serhal, Sioban B, Sengupta   +5 more
openaire   +2 more sources

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Association between telomere shortening and ageing during occupational exposure [PDF]

Journal of Medical Biochemistry, 2012
Telomere length is considered as a biomarker of ageing, resulting in shortening during the process. The present investigation was an attempt to determine the relative telomere length in mechanical workshop workers.
Sima Ataollahi Eshkoor, Fatemeh Jahanshiri, Patimah Ismail, Sabariah Abd Rahman, Moin Saidi, Mohd Yusoff Adon   +5 more
doaj  

Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population

Clinical and Research Journal in Internal Medicine, 2023
Background: Obesity is a prominent avoidable cause of mortality and a growing health concern in both adults and children throughout the world. The study's goal is to measure leucocyte telomere length and its relationship with leptin throughout the BMI ...
Anurag Yadav, L G Nandakumar, Anmol Manaswini Golla Yadav, Srivats Golla Yadav, Kaveri N Karewad   +4 more
doaj   +1 more source

Telomere erosion in NF1 tumorigenesis [PDF]

, 2017
Neurofibromatosis type 1 (NF1; MIM# 162200) is a familial cancer syndrome that affects 1 in 3,500 individuals worldwide and is inherited in an autosomal dominant fashion.
Baird, Duncan, Grimstead, Julia, Robinson, Rhiannon, Sedani, Ashni, Upadhyaya, Meena   +4 more
core   +2 more sources

Telomere length and cardiovascular aging

Annals of Medicine, 2012
Telomeres are located at the end of chromosomes. They are composed of repetitive TTAGGG tandem repeats and associated proteins of crucial importance for telomere function. Telomeric DNA is shortened by each cell division until a critical length is achieved and the cell enters senescence and eventually apoptosis.
Frej, Fyhrquist, Outi, Saijonmaa
openaire   +2 more sources