Results 81 to 90 of about 110,609 (302)

Telomere Length: Implications for Atherogenesis

Current Atherosclerosis Reports, 2023
Abstract Purpose of Review The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease. Recent Findings There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence ...
Hao Yin, J. Geoffrey Pickering
openaire   +2 more sources

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization

Nature Communications
The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases; however there is limited knowledge of biological signals that regulate inheritance of telomere length, and ...
Yasmyn E. Winstanley, Ryan D. Rose, Alexander P. Sobinoff, Linda L. Wu, Deepak Adhikari, Qing-Hua Zhang, Jadon K. Wells, Lee H. Wong, Hazel H. Szeto, Sandra G. Piltz, Paul Q. Thomas, Mark A. Febbraio, John Carroll, Hilda A. Pickett, Darryl L. Russell, Rebecca L. Robker   +15 more
doaj   +1 more source

Is telomere length associated with mate choice in a songbird with a high rate of extra-pair paternity? [PDF]

PLoS ONE, 2017
Telomere length is related to aging in many eukaryotes and the rate of telomere attrition has been suggested to reflect individual genetic quality. Telomere length could thus have implications for mate choice. We investigated telomere length variation in
Arild Johnsen, Angela Pauliny, Jan T Lifjeld, Donald Blomqvist   +3 more
doaj   +1 more source

Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic modifying drug [PDF]

, 2016
Background: Telomere length dysregulation plays a major role in cancer development and aging. Telomeres are maintained by a group of specialized genes known as shelterin and shelterin-associated proteins.
Mirabdulhagh, M, Motevalli, A, Roberts, T, Slijepcevic, P, Virmouni, SA, Yasaei, H   +5 more
core   +1 more source

Mammalian chromosome–telomere length dynamics [PDF]

Royal Society Open Science, 2018
Individual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the associations across disparate taxa suggest that this is ...
Amy R. Klegarth, Dan T. A. Eisenberg
openaire   +3 more sources

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Association between exposure to second-hand smoke and telomere length: cross-sectional study of 1303 non-smokers [PDF]

, 2017
Background: Both active smoking and second-hand smoke (SHS) are important risk factors for many age-related diseases. Active smoking is associated with shortened telomere length. However, whether SHS accelerates telomere attrition with age is uncertain.
Johnman, Cathy, Lu, Liya, Mackay, Daniel F., McGlynn, Liane, Pell, Jill P., Shiels, Paul G.   +5 more
core   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Short telomeres initiate telomere recombination in primary and tumor cells. [PDF]

PLoS Genetics, 2009
Human tumors that lack telomerase maintain telomeres by alternative lengthening mechanisms. Tumors can also form in telomerase-deficient mice; however, the genetic mechanism responsible for tumor growth without telomerase is unknown.
Tammy A Morrish, Carol W Greider
doaj   +1 more source