Results 11 to 20 of about 627 (158)

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis [PDF]

Advanced Science
Temporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function ...
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
doaj   +3 more sources

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding [PDF]

Advanced Science
The innate immune response is crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). Yet, the roles of eosinophils in TMJOA remain unclear, underscoring the need for further investigation into their potential impact and mechanism ...
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
doaj   +3 more sources

Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease [PDF]

Journal of Anatomy, EarlyView.
The temporomandibular joint (TMJ) plays a key role in facilitating complex mammalian jaw movements required for daily life. It is formed between the condylar process of the mandible (or dentary bone) of the lower jaw, the glenoid (or mandibular) fossa of
Anthwal, Neal, Belisova, Denisa, Sumbalova Koledova, Zuzana, Tucker, Abigail S., Tuwatnawanit, Ticha   +4 more
core   +2 more sources

Microgel Encapsulated Mesoporous Silica Nanoparticles for Releasing Wnt16 to Synergistically Treat Temporomandibular Joint Osteoarthritis

Advanced Science
Temporomandibular joint osteoarthritis (TMJOA) is a commonly encountered degenerative joint disease in oral and maxillofacial surgery. Recent studies have shown that the excessive unbalanced activation of Wnt/β‐catenin signaling is connected with the ...
Yan Zhu, Lingyan Cao, Mu Yuan, Xuzhuo Chen, Xinru Xie, Minhan Li, Chi Yang, Xiansong Wang, Zhigui Ma   +8 more
doaj   +2 more sources

Artificial Cell-Derived Vesicles: Extracellular Vesicle Mimetics for Chondrocyte Restoration in TMJOA Therapy. [PDF]

Int J Nanomedicine
Yu Hu,1,* Guobin Huang,2,3,* Zichao Dai,2,3 Rongqiang Yang,2,3 Yang Zhang,4 Yelin Zhang,2,3 Huilin Shen,2,3 Zhu Pu,2,3 Liya Ma,2,3 Song Li2,3 1Outpatient Department, Kunming Medical University School and Hospital of Stomatology, Kunming, 650106 ...
Hu Y, Huang G, Dai Z, Yang R, Zhang Y, Zhang Y, Shen H, Pu Z, Ma L, Li S.   +9 more
europepmc   +3 more sources

Engineered M2 macrophage-derived extracellular vesicles reprogram mitochondrial metabolism to alleviate temporomandibular joint cartilage degeneration [PDF]

Materials Today Bio
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative joint disease characterized by progressive degradation of the cartilage matrix. Current clinical interventions mainly offer symptomatic relief but fail to halt disease progression.
Weiwen Ge, Lei Qi, Yun Wang, Jing Wang, Xin Fang, Shixue Lei, Dan Lin, Lei Zhang, Shanyong Zhang   +8 more
doaj   +2 more sources

USP32 promotes temporomandibular joint osteoarthritis by modulating PKM2 stability and glycolytic metabolism in chondrocytes [PDF]

Cell Death and Disease
Metabolic alterations in chondrocytes play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). However, the precise molecular mechanisms underlying these changes remain poorly understood.
Jiamin Zhao, Runjing Li, Tianjing Du, Mengying Wang, Menghong Li, Zhihui Feng, Zhongbo Liu, Kun Qi   +7 more
doaj   +2 more sources

RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA [PDF]

Arthritis Research & Therapy
Background E3 ubiquitin ligases are established regulators of osteoarthritis pathogenesis known to amplify inflammatory signals via substrate protein destabilization, but their role in temporomandibular joint osteoarthritis (TMJOA) remains elusive ...
Xinjian Zhang, Qingkun Jiang, Wei Deng, Hai Tang, Yang Liu, Zichen Xu, Ke Guo, Ning Liu, Haitao Wang, Tiehan Cui, Fang Wang, Jiaxuan Qiu   +11 more
doaj   +2 more sources

17β‐estradiol promotes the progression of temporomandibular joint osteoarthritis by regulating the FTO/IGF2BP1/m6A‐NLRC5 axis

Immunity, Inflammation and Disease
Background Temporomandibular joint osteoarthritis (TMJOA) is a degenerative cartilage disease. 17β‐estradiol (E2) aggravates the pathological process of TMJOA; however, the mechanisms of its action have not been elucidated.
Xintong Xue, Changyi Li, Shuang Chen, Yan Zheng, Fan Zhang, Yan Xu   +5 more
doaj   +2 more sources

Mapping cell diversity and dynamics in inflammatory temporomandibular joint osteoarthritis with pain at single-cell resolution [PDF]

JCI Insight
Temporomandibular joint (TMJ) osteoarthritis with pain is a highly prevalent disorder affecting patients’ quality of life. A comprehensive understanding of cell type diversity and its dynamics in painful TMJ osteoarthritis (TMJOA) is lacking.
Supawadee Jariyasakulroj, Yang Shu, Ziying Lin, Jingyi Chen, Qing Chang, Pao-Fen Ko, Jian-Fu Chen   +6 more
doaj   +2 more sources