Arthritis Research and Therapy, 2023 Objectives Innate immunity plays a significant role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA), which is characterized by synovial inflammation and condylar cartilage degradation.
Xing Long
exaly +4 more sources
Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis [PDF]
Small ScienceCurrent clinical interventions lack effective strategies to arrest temporomandibular joint osteoarthritis (TMJOA) progression. Emerging evidence highlights the therapeutic potential of microRNAs (miRNAs) in osteoarthritis (OA) management, though critical
Wenxiu Yuan +11 more
doaj +3 more sources
Comparative review: clinical and pathological heterogeneity in knee versus temporomandibular joint osteoarthritis [PDF]
Frontiers in Bioengineering and BiotechnologyTemporomandibular joint osteoarthritis (TMJOA) remains a clinically underrecognized and insufficiently studied disorder, despite exerting a comparable impact on quality of life as knee osteoarthritis (knee OA).
Jiannan Zhao +5 more
doaj +5 more sources
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA [PDF]
Arthritis Research and TherapyBackground E3 ubiquitin ligases are established regulators of osteoarthritis pathogenesis known to amplify inflammatory signals via substrate protein destabilization, but their role in temporomandibular joint osteoarthritis (TMJOA) remains elusive ...
Xinjian Zhang +11 more
exaly +3 more sources
Infiltrated Macrophages Aggravate TMJOA Chronic Pain via Piezo2 in IB4 + ‐ TG Neurons [PDF]
Oral DiseasesObjective: Recent research indicates that macrophages in ganglia are linked to chronic pain, with Piezo2 ion channels playing a key role in pain sensation.
Jin Ke
exaly +5 more sources
CAT/SOD-Enriched Achyranthes bidentata nanovesicles mitigate TMJOA via ROS scavenging and JNK/FOXO1 pathway Inhibition [PDF]
Journal of NanobiotechnologyTemporomandibular joint osteoarthritis (TMJOA) is an inflammatory disorder with limited treatment options. Given the key role of oxidative stress in TMJOA progression, targeting this pathway may offer therapeutic benefits.
Antong Wu
exaly +3 more sources
Extracellular vesicles from adipose-derived stromal/stem cells reprogram dendritic cells to alleviate rat TMJOA by transferring mitochondria [PDF]
Journal of NanobiotechnologyTemporomandibular joint osteoarthritis (TMJOA) urgently needs regenerative therapies due to the limited effects of traditional treatments. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are considered a potent alternative for MSC therapy ...
Ziyi Mei +9 more
exaly +3 more sources
Identification of HK3 as a Potential Key Biomarker in the Progression of Temporomandibular Joint Osteoarthritis via RNA Sequencing [PDF]
BiologyThe pathogenesis of temporomandibular joint osteoarthritis (TMJOA) is poorly understood. This study aims to identify key biomarkers involved in TMJOA progression and explore potential therapeutic drugs through transcriptome analysis.
Ping Luo +3 more
doaj +2 more sources
METTL3-mediated fibroblast-like synoviocytes senescence promotes temporomandibular joint osteoarthritis progression [PDF]
Communications BiologyTemporomandibular joint osteoarthritis (TMJOA) is a disease that affects the TMJ and is associated with degenerative changes in the articular cartilage. Fibroblast-like synoviocytes (FLSs) have been found to contribute to osteoarthritis.
Kun Tian +8 more
doaj +2 more sources
Bibliometric and visualization analysis of temporomandibular joint osteoarthritis from 2004 to 2024 [PDF]
Frontiers in Oral HealthBackgroundTemporomandibular joint osteoarthritis (TMJOA) is a severe condition affecting the temporomandibular joint, impairing essential oral functions such as chewing, speaking, and swallowing.
Chi Xu +11 more
doaj +2 more sources