Results 21 to 30 of about 771 (176)

17β‐estradiol promotes the progression of temporomandibular joint osteoarthritis by regulating the FTO/IGF2BP1/m6A‐NLRC5 axis

Immunity, Inflammation and Disease
Background Temporomandibular joint osteoarthritis (TMJOA) is a degenerative cartilage disease. 17β‐estradiol (E2) aggravates the pathological process of TMJOA; however, the mechanisms of its action have not been elucidated.
Xintong Xue, Changyi Li, Shuang Chen, Yan Zheng, Fan Zhang, Yan Xu   +5 more
doaj   +2 more sources

Microgel Encapsulated Mesoporous Silica Nanoparticles for Releasing Wnt16 to Synergistically Treat Temporomandibular Joint Osteoarthritis

Advanced Science
Temporomandibular joint osteoarthritis (TMJOA) is a commonly encountered degenerative joint disease in oral and maxillofacial surgery. Recent studies have shown that the excessive unbalanced activation of Wnt/β‐catenin signaling is connected with the ...
Yan Zhu, Lingyan Cao, Mu Yuan, Xuzhuo Chen, Xinru Xie, Minhan Li, Chi Yang, Xiansong Wang, Zhigui Ma   +8 more
doaj   +2 more sources

Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis [PDF]

Journal of Nanobiotechnology
Temporomandibular joint osteoarthritis (TMJOA) is a multifaceted degenerative disease characterized by progressive cartilage degradation, chronic pain, and functional limitations of the TMJ, significantly affecting patients’ quality of life.
Xiaofeng Hu, Jian Xie, Jiansheng Su
doaj   +2 more sources

Mechanical Overloading Induces Chondrocyte Ferroptosis In Tmjoa Through Piezo1 Channel

International Dental Journal
Aim or purpose: To investigate whether condylar mechanical overloading induces ferroptosis and TMJOA, and to explore the underlying mechanisms. Materials and methods: TMJOA models were generated in rats through increased bilateral occlusal vertical ...
Yucheng Wang, Bin Shi
doaj   +2 more sources

Osteoarthritis of the Temporomandibular Joint: A Narrative Overview

Medicina, 2022
Background and Objectives: This study reviewed the literature to summarize the current and recent knowledge of temporomandibular joint osteoarthritis (TMJOA).
Caroline Mélou, Pascal Pellen-Mussi, Sylvie Jeanne, Agnès Novella, Sylvie Tricot-Doleux, Dominique Chauvel-Lebret   +5 more
doaj   +1 more source

Drug delivery systems for treatment of temporomandibular joint osteoarthritis

Frontiers in Pharmacology, 2022
The number of people suffering from temporomandibular joint osteoarthritis (TMJOA) has been increasing. TMJOA cause joint noise, pain on TMJ and/or masticatory muscles, and restricted mandibular movement, which disturb eating, laughing and conversation ...
Xinqi Huang, Xuefeng Pan, Xiner Xiong, Zhihe Zhao, Xiao Cen   +4 more
doaj   +1 more source

Isolate or combined use of platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis: a concise systematic review [PDF]

, 2023
Introduction: In the context of temporomandibular disorders (TMD), temporomandibular joint osteoarthritis (TMJOA) is a common disease in the oral and maxillofacial regions, as well as being the most severe type.
Alves Filho, Carlos Alberto, Beneti, Igor Mariotto, Costa, Monique, Manna, Camila Alves   +3 more
core   +2 more sources

Fractal Analysis of Subchondral Cyst at Mandibular Condyle Detected on Panoramic Radiograph in A Group of Thai Population [PDF]

, 2022
Objectives: This study aimed to analyze subchondral cyst on the mandibular condyle using fractal dimension (FD) measurement on a panoramic radiograph. Methods: This retrospective study examined 15 patients aged 24 to 75 years who had undergone panoramic ...
Janhom, Apirum, Pornprasertsuk-Damrongsri, Suchaya, Srimawong, Preeyaporn, Wijanarko, Aloysius Putut   +3 more
core   +2 more sources

Targeting NLRP3 Inflammasome Alleviates Synovitis by Reducing Pyroptosis in Rats with Experimental Temporomandibular Joint Osteoarthritis

Mediators of Inflammation, 2022
The mechanism of temporomandibular joint osteoarthritis (TMJOA), which leads to the final erosion of cartilage and subchondral bone, has been widely demonstrated, but still not clearly elucidated.
Yinzi Xin, Wei Wang, Enyu Mao, Hefeng Yang, Song Li   +4 more
doaj   +1 more source

Kartogenin potentially protects temporomandibular joints from collagenase-induced osteoarthritis via core binding factor β and runt-related transcription factor 1 binding - A rat model study

Journal of Dental Sciences, 2023
Background/purpose: Temporomandibular joint (TMJ) osteoarthritis (TMJOA) is a chronic disease with progressive destruction of articular cartilage. This study aimed to explore the therapeutic effects of kartogenin on TMJOA via promoting the binding of ...
Li Ye, Zhiwei Cao, Xing Tan, Chengzhi Zhao, Yubin Cao, Jian Pan   +5 more
doaj   +1 more source